As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Sirtuin 1 (SIRT1) is a histone deacetylase belonging to the family of Sirtuins, a class of
nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic …

Background—Vascular smooth muscle cells (VSMCs) in human atherosclerosis manifest
extensive DNA damage and activation of the DNA damage response, a pathway that …

SIRT1, a member of the sirtuin family of longevity regulators, possesses potent activities
preventing vascular aging. The expression and function of SIRT1 in endothelial cells are …

Purpose Endothelial dysfunction and inflammation are conditions which fuel atherosclerosis
and ischaemic heart disease. We have previously reported reduced cardiovascular (CV) …

Selenium, reported as an important medium for maintaining the body's homeostasis, acts to
have multiple bioeffects including anti-inflammatory, anti-oxidant and anti-apoptosis effects …

Background Systemic inflammatory response could affect many systems. Cardiac
dysfunction develops due to cardiovascular system damage and could be mortal. Selenium …

Aging is the common cause for multiple diseases, including cardiovascular disease (CVD),
which is the leading cause of death worldwide. The desire of humans to prolong life dates …

atherosclerosis is a chronic and progressive disease. its morbidity and mortality rates have
demonstrated an increase in recent years. The present study aimed to explore the role of …

Growing evidence shows that acute and chronic overproduction of reactive oxygen species
(ROS) and increased oxidants under pathophysiologic circumstances are of vital importance …