We commend Zernig et al.(2003) for trying to incorporate incentive-sensitization concepts
into traditional behavioral pharmacology. However, their present formulation suffers from …

Most adults have used a potentially addictive drug at least once in their lifetime, if caffeine,
alcohol, and nicotine are included in addition to illicit drugs. In some cases, contact with a …

The focus of most research in the area of substance abuse has been on the factors that
motivate or facilitate drug use, especially those relating to the rewarding properties of drugs …

This paper reviews recent developments in the neurocircuitry and neurobiology of addiction
from a perspective of allostasis. A model is proposed for brain changes that occur during the …

Reviews recent behavioral and neuropharmacological findings, which suggest that opiate
and stimulant drugs act on common neurochemical systems of the brain to generate positive …

Based on brain imaging findings, we present a model according to which addiction emerges
as an imbalance in the information processing and integration among various brain circuits …

The development of tolerance and dependence has long been considered an integral part
of drug addiction, but has lost its impact in drug dependence theory due to new emphasis on …

Modern neuroscience has greatly increased our understanding of the phenomenology of
addiction. Using animal models as well as human brain imaging studies and clinical …

Drug addiction can be conceptualized as a disturbance of behavior motivated by drug-
conditioned incentives. This abnormality has been explained by Incentive-Sensitization and …

A central premise of a number of theories of addiction is that discrete environmental stimuli
repeatedly paired with drugs of abuse acquire incentive salience as a result of Pavlovian …