Natural product-based multitargeted ligands for Alzheimer's disease treatment?

NT Tzvetkov, AG Atanasov - Future Medicinal Chemistry, 2018 - Future Science
Alzheimer's disease (AD) belongs to the most intensively investigated and discussed
disorders in modern medicine and community worldwide. Only few clinical diagnoses evoke …

The molecular mechanism, targets, and novel molecules in the treatment of Alzheimer's disease

A Verma, DK Waiker, B Bhardwaj, P Saraf… - Bioorganic …, 2022 - Elsevier
Alzheimer's disease (AD) is a progressive neurological illness that causes dementia mainly
in the elderly. The challenging obstacles related to AD has freaked global healthcare system …

Review of drugs for Alzheimer's disease

X Sun, L Jin, P Ling - Drug discoveries & therapeutics, 2012 - jstage.jst.go.jp
Alzheimer's disease (AD) is the most common form of dementia in the elderly. The number of
people affected by AD is rapidly increasing. AD is characterized by cerebral atrophy …

Reducing Aβ load and tau phosphorylation: Emerging perspective for treating Alzheimer's disease

J Kalra, A Khan - European journal of pharmacology, 2015 - Elsevier
Alzheimer's disease (AD) is a complex, progressive neurological disorder affecting elderly
population of above 65 years of age, characterized by failure of memory, loss of acquired …

Molecular and biochemical features in Alzheimer's disease

M Pallas, A Camins - Current pharmaceutical design, 2006 - ingentaconnect.com
The purpose of this review is to discuss the pathophysiological pathways involved in
pathogenesis of Alzheimer's disease pointing out current and future pharmacological …

Current concepts of neurodegenerative mechanisms in Alzheimer's disease

KB Magalingam, A Radhakrishnan… - BioMed research …, 2018 - Wiley Online Library
Neurodegenerative diseases are hereditary or sporadic conditions that result in the
progressive loss of the structure and function of neurons as well as neuronal death …

Pharmacological approaches for Alzheimer's disease: Neurotransmitter as drug targets

A Prakash, J Kalra, V Mani, K Ramasamy… - Expert review of …, 2015 - Taylor & Francis
Alzheimer's disease (AD) is the most common CNS disorder occurring worldwide. There is
neither proven effective prevention for AD nor a cure for patients with this disorder. Hence …

Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer's Disease: Recent Trends and Future Development

BP Dave, YB Shah, KG Maheshwari… - Cellular and Molecular …, 2023 - Springer
Alzheimer's disease (AD) is the primary cause of dementia and is characterized by the death
of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of …

[PDF][PDF] Pharmacological treatment for Alzheimer's disease: current approaches and future strategies

LY Fan, MJ Chiu - Acta Neurol Taiwan, 2010 - ant-tnsjournal.com
More than a decade after the first approval of the use of acetylcholine esterase inhibitor on
patients with Alzheimer's disease, we still not have a single treatment or combination …

Alzheimer's disease: a review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment

P dos Santos, C Leide, PF Ozela… - Current medicinal …, 2018 - ingentaconnect.com
Dementia is characterized by the impairment of cognition and behavior of people over 65
years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the …