Caenorhabditis elegans-on-a-chip: microfluidic platforms for high-resolution imaging and phenotyping
S Mondal, A Ben-Yakar - Organ-on-a-chip, 2020 - Elsevier
Caenorhabditis elegans is an attractive alternative animal model for identifying toxicological
phenotypes in vivo, studying the mode of action of drugs, and characterizing physiological …
phenotypes in vivo, studying the mode of action of drugs, and characterizing physiological …
Microfluidic Technologies for High Throughput Screening Through Sorting and On-Chip Culture of C. elegans
D Midkiff, A San-Miguel - Molecules, 2019 - mdpi.com
The nematode Caenorhabditis elegans is a powerful model organism that has been widely
used to study molecular biology, cell development, neurobiology, and aging. Despite their …
used to study molecular biology, cell development, neurobiology, and aging. Despite their …
vivoBodySeg: Machine learning-based analysis of C. elegans immobilized in vivoChip for automated developmental toxicity testing
A DuPlissis, A Medewar, E Hegarty, A Laing, A Shen… - 2024 - researchsquare.com
Developmental toxicity (DevTox) tests evaluate the adverse effects of chemical exposures
on an organism's development. While large animal tests are currently heavily relied on, the …
on an organism's development. While large animal tests are currently heavily relied on, the …
Microfluidic Systems for Whole‐Animal Screening with C. elegans
N Ghorashian, SK Gökçe… - Micro‐and Nanosystems …, 2016 - Wiley Online Library
In this chapter, we discuss the biological relevance of the nematode, Caenorhabditis
elegans (C. elegans) in studying human disease and injury, and how it is amenable to high …
elegans (C. elegans) in studying human disease and injury, and how it is amenable to high …
An automated microfluidic platform for toxicity testing based on Caenorhabditis elegans
J Wu, J Xi, Z Zhu, Q Peng, C Liu, Z Wan, Y Cao, X Chen… - bioRxiv, 2024 - biorxiv.org
Humans are frequently exposed to a multitude of chemicals daily, necessitating efficient
methods for rapidly assessing toxicity and potential health risks. Microfluidics has shown …
methods for rapidly assessing toxicity and potential health risks. Microfluidics has shown …
On-chip phenotypic screening and characterization of C. elegans enabled by microfluidics and image analysis methods
IC Cáceres Mendieta - 2013 - repository.gatech.edu
Since its introduction in 1960's, the model organism Caenorhabditis elegans has played a
crucial role towards scientific discoveries because of its relatively simple anatomy …
crucial role towards scientific discoveries because of its relatively simple anatomy …
Automated microfluidic platforms to facilitate nerve degeneration studies with C. elegans
N Ghorashian - 2013 - repositories.lib.utexas.edu
With its well-characterized genome, simple anatomy, and vast array of uses in molecular
biology, the roundworm, Caenorhabditis elegans (C. elegans) is a well-established model …
biology, the roundworm, Caenorhabditis elegans (C. elegans) is a well-established model …
C. elegans in high-throughput drug discovery
LP O'Reilly, CJ Luke, DH Perlmutter… - Advanced drug delivery …, 2014 - Elsevier
Caenorhabditis elegans has been proven to be a useful model organism for investigating
molecular and cellular aspects of numerous human diseases. More recently, investigators …
molecular and cellular aspects of numerous human diseases. More recently, investigators …
Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans
M Cornaglia, T Lehnert, MAM Gijs - Lab on a Chip, 2017 - pubs.rsc.org
In a typical high-throughput drug screening (HTS) process, up to millions of chemical
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …
Phenotyping C. elegans and neuronal cells in microengineered devices
RJ Lycke - 2012 - search.proquest.com
Phenotype denotes the observable traits or behaviors of any living subject such as cells,
animals, and humans. In the post-genomics era, the next major challenge in the biological …
animals, and humans. In the post-genomics era, the next major challenge in the biological …