Casein kinase-2 (CK2) probably is the most pleiotropic member of the protein kinase family,
with more than 200 substrates known to date. Unlike the great majority of protein kinases …

Background: Cyclin-dependent kinase 2 (CDK2) has been studied due to its role in the cell-
cycle progression. The elucidation of the CDK2 structure paved the way to investigate the …

Protein kinase CK2 (Casein Kinase 2) is an essential, ubiquitous and highly pleiotropic
protein kinase, implicated in several human diseases. In the last decade, several inhibitors …

Cyclin-dependent kinases (CDKs) are regulatory proteins of the eukaryotic cell cycle. They
act after association with different cyclins, the concentrations of which vary throughout the …

Chrysin (5, 7-dihydroxyflavone), a natural flavonoid widely distributed in plants, reportedly
has chemopreventive properties against various cancers. However, the anticancer activity of …

Cyclin-dependent kinases (CDKs) play a central role in cell cycle control, apoptosis,
transcription, and neuronal functions. They are important targets for the design of drugs with …

Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase
whose abnormally high constitutive activity is suspected to underlie its pathogenic potential …

Alzheimer's disease (AD) is a progressive neurodegenerative disease with no cure till today.
Aberrant activation of cell cycle regulatory proteins is implicated in neurodegenerative …

In eukaryotes, protein phosphorylation of serine, threonine or tyrosine residues by protein
kinases plays an important role in many cellular processes. Members of the protein kinase …

Aberrations in cell cycle progression occur in the majority of human malignancies. The main
pathway affected is the retinoblastoma (Rb) pathway. The tumor suppressor gene Rb is an …