[HTML][HTML] Healthy effects of plant polyphenols: molecular mechanisms

M Leri, M Scuto, ML Ontario, V Calabrese… - International journal of …, 2020 - mdpi.com
The increasing extension in life expectancy of human beings in developed countries is
accompanied by a progressively greater rate of degenerative diseases associated with …

Antioxidant activity of plant phenols: chemical mechanisms and biological significance

O Dangles - Current Organic Chemistry, 2012 - ingentaconnect.com
Polyphenols having catechol (1, 2-dihydroxybenzene) nuclei are strong in vitro antioxidants
owing to their ability to rapidly reduce reactive oxygen species (ROS), bind transition metal …

Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence

L Chen, H Teng, Z Jia, M Battino, A Miron… - Critical reviews in …, 2018 - Taylor & Francis
Dietary flavonoids, which occur in many plant foods, are considered as the most active
constituents among the plant-derived ones in vitro and in vivo. To date, many studies have …

Basic biochemical mechanisms behind the health benefits of polyphenols

CG Fraga, M Galleano, SV Verstraeten… - Molecular aspects of …, 2010 - Elsevier
Polyphenols and consequently many flavonoids have several beneficial actions on human
health. However, the actual molecular interactions of polyphenols with biological systems …

[HTML][HTML] Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases

P Chaudhary, P Janmeda, AO Docea… - Frontiers in …, 2023 - frontiersin.org
Introduction: Free radicals are reactive oxygen species that constantly circulate through the
body and occur as a side effect of many reactions that take place in the human body. Under …

[PDF][PDF] The interplay of oxidative stress and inflammation: mechanistic insights and therapeutic potential of antioxidants

AM Mahmoud, FL Wilkinson, MA Sandhu… - … Medicine and Cellular …, 2021 - researchgate.net
Oxidative stress is caused by the overproduction of Reactive Oxygen Species (ROS) and
diminished cellular antioxidant defenses. Under physiological conditions, ROS are involved …

Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox?

SK Biswas - Oxidative medicine and cellular longevity, 2016 - Wiley Online Library
Oxidative stress has been implicated in many chronic diseases. However, antioxidant trials
are so far largely unsuccessful as a preventive or curative measure. Chronic low‐grade …

The synergistic anti-inflammatory effects of lycopene, lutein, β-carotene, and carnosic acid combinations via redox-based inhibition of NF-κB signaling

N Hadad, R Levy - Free Radical Biology and Medicine, 2012 - Elsevier
Inflammatory mediators and cytokines play important roles in the pathogenesis of a vast
number of human diseases; therefore much attention is focused on blunting their …

[HTML][HTML] Polyphenols from food and natural products: Neuroprotection and safety

RFM Silva, L Pogačnik - Antioxidants, 2020 - mdpi.com
Polyphenols are naturally occurring micronutrients that are present in many food sources.
Besides being potent antioxidants, these molecules may also possess anti-inflammatory …

Anti-inflammatory plant flavonoids and cellular action mechanisms

HP Kim, KH Son, HW Chang, SS Kang - Journal of pharmacological …, 2004 - jstage.jst.go.jp
Plant flavonoids show anti-inflammatory activity in vitro and in vivo. Although not fully
understood, several action mechanisms are proposed to explain in vivo anti-inflammatory …