Purpose Tetracyclines have activity against matrix metalloproteinases (MMP). Oral
medications with effects on the ocular surface are of interest in patients where repeated …

Objective—To examine in vitro effects of various antiproteolytic compounds on activity of
matrix metalloproteinase (MMP)-2 and-9 in the tear film of horses with active corneal ulcers …

Reasons for performing study: Minocycline holds great potential for use in horses not only
for its antimicrobial effects but also for its anti‐inflammatory and neuroprotective properties …

Objective Levels of tear film matrix metalloproteinases (MMPs) activity are significantly
elevated in horses with ulcerative keratitis and contribute to the excessive breakdown of …

Objective To determine the concentration of doxycycline in preocular tear film following oral
administration in horses as a possible therapeutic modality for infectious and keratomalacic …

Objective—To determine the pharmacokinetics and tissue distribution of minocycline in
horses. Animals—5 healthy Thoroughbred mares for the pharmacokinetic experiment and 6 …

Purpose: Tear film proteinases are produced and released by corneal epithelial cells,
stromal fibroblasts, leukocytes, and microbial pathogens. Excessive levels of tear film …

The cornea and precorneal tear film combine to function as a strong refractive lens. To
produce such an optically powerful structure, the corneal microanatomy consists of an …

Objective Compare the efficacy of canine serum, fresh frozen plasma (FFP), freeze–thaw‐
cycled plasma (FTCP), and S olcoseryl™ at inhibiting matrix metalloproteinases (MMP) 2 …

Ulcerative keratitis is a common and potentially blinding ocular disease of horses, capable
of progressing to corneal perforation in as little as 24 h. This rapid stromal degeneration is …