Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection
S Crotta, M Brazzoli, D Piccioli, NM Valiante… - Journal of hepatology, 2010 - Elsevier
BACKGROUND & AIMS: Hepatitis C virus (HCV) is remarkably successful in establishing
persistent infections due to its ability to evade host immune responses through a …
persistent infections due to its ability to evade host immune responses through a …
[PDF][PDF] Natural killer cell function is intact after direct exposure to infectious hepatitis C virions
JC Yoon, M Shiina, G Ahlenstiel, B Rehermann - Hepatology, 2009 - Wiley Online Library
Although hepatitis C virus (HCV) has been shown to readily escape from virus‐specific T
and B cell responses, its effects on natural killer (NK) cells are less clear. Based on two …
and B cell responses, its effects on natural killer (NK) cells are less clear. Based on two …
Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein
The immune response against hepatitis C virus (HCV) is rarely effective at clearing the virus,
resulting in∼ 170 million chronic HCV infections worldwide. Here we report that ligation of …
resulting in∼ 170 million chronic HCV infections worldwide. Here we report that ligation of …
Cytokine-activated natural killer cells exert direct killing of hepatoma cells harboring hepatitis C virus replicons
Hepatitis C virus (HCV)-specific impairments in host immunity have been described at
multiple levels of the innate and adaptive response, which may lead to viral persistence in …
multiple levels of the innate and adaptive response, which may lead to viral persistence in …
Cell-to-cell contact with hepatitis C virus-infected cells reduces functional capacity of natural killer cells
JC Yoon, JB Lim, JH Park, JM Lee - Journal of virology, 2011 - Am Soc Microbiol
The distinct feature of hepatitis C virus (HCV) infection is a high incidence of chronicity. The
reason for chronic HCV infection has been actively investigated, and impairment of innate …
reason for chronic HCV infection has been actively investigated, and impairment of innate …
Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis
Natural killer (NK) cells constitute the first line of host defense against invading pathogens.
They usually become activated in an early phase of a viral infection. Liver is particularly …
They usually become activated in an early phase of a viral infection. Liver is particularly …
Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions
CTK Tseng, GR Klimpel - The Journal of experimental medicine, 2002 - rupress.org
Infection with hepatitis C virus (HCV) is a leading cause of chronic liver disease worldwide.
Little is known about how this virus is able to persist or whether this persistence might be …
Little is known about how this virus is able to persist or whether this persistence might be …
[HTML][HTML] Natural killer cells in hepatitis C: Current progress
JC Yoon, CM Yang, Y Song, JM Lee - World journal of …, 2016 - ncbi.nlm.nih.gov
Patients infected with the hepatitis C virus (HCV) are characterized by a high incidence of
chronic infection, which results in chronic hepatitis, liver cirrhosis, and hepatocellular …
chronic infection, which results in chronic hepatitis, liver cirrhosis, and hepatocellular …
Activation of natural killer cells during acute infection with hepatitis C virus
B Amadei, S Urbani, A Cazaly, P Fisicaro, A Zerbini… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Natural killer (NK) cells are essential early after infection, not only
for viral containment but also for timely and efficient induction of adaptive responses. An …
for viral containment but also for timely and efficient induction of adaptive responses. An …
[PDF][PDF] Natural killer cells: primary target for hepatitis C virus immune evasion strategies?
L Golden‐Mason, HR Rosen - Liver Transplantation, 2006 - Wiley Online Library
Liver cirrhosis and hepatocellular carcinoma secondary to chronic hepatitis C virus (HCV)
infection requiring transplantation represents a significant public health problem. The most …
infection requiring transplantation represents a significant public health problem. The most …