The idea that an abnormality in the β 2-adrenergic receptor contributes to asthma has been
a long-standing hypothesis. Since the discovery of functionally relevant polymorphisms in …

Because of its involvement in the regulation of airway tone, the β2-adrenoreceptor is
considered a candidate for bronchial hyperresponsiveness (BHR) associated with asthma …

Summary Beta‐2‐Adrenergic receptors (β2AR) participate in the physiologic responses of
the lung, including bronchodilation and bronchoprotection, through mechanisms such as …

Polymorphisms of ADRB2 are not major risk factors for the development of asthma. These
polymorphisms are likely to be important, however, in determining drug response. Future …

Background The β 2-adrenergic receptor gene is one of the most extensively studied genes
with respect to asthma prevalence and severity. The Arg16Gly and Gln27Glu polymorphisms …

Asthma is a polygenic disease for which no clear genotype-phenotype relationships have
emerged. In contrast, although not associated with the diagnosis of asthma per se, variant …

Genetic variation in the β2-adrenoceptor and its associated proteins is common and
therefore potentially relevant to the clinician. Several functional SNPs have been described …

Cite this as: LP Chung, G. Waterer and PJ Thompson, Clinical & Experimental Allergy, 2011
(41) 312–326. Summary Adrenergic β2 receptor (ADRβ2) agonists are widely used in …

The β2-adrenergic receptor (β2AR) is the molecular target for β-agonists used in the
treatment of asthma. In the human population, 4 polymorphisms of the β2AR coding block …

Background There are a number of candidate genes thought to play a role in the
development of asthma. Polymorphisms at amino acid positions 16 (arginine to glycine) and …