Berberine is a plant alkaloid with anti-diabetic action. Activation of AMP-activated protein
kinase (AMPK) pathway has been proposed as mechanism for berberine's action. This study …

Berberine has been shown to have antidiabetic properties, although its mode of action is not
known. Here, we have investigated the metabolic effects of berberine in two animal models …

Berberine (BER), a natural product and active ingredient of genera Berberis and Coptis, has
been demonstrated to possess anti-diabetic activities. However, the poor bioavailability of …

Berberine, a botanical alkaloid used to control blood glucose in type 2 diabetes in China,
has recently been reported to activate AMPK. However, it is not clear how AMPK is activated …

Aim This study is designed to investigate whether or not AMP-activated protein kinase α1
(AMPKα1) is required for natural product berberine (BBR) to improve glucose and lipid …

Berberine, a hypoglycemic agent, has recently been shown to activate AMP-activated
protein kinase (AMPK) contributing to its beneficial metabolic effects in peripheral tissues …

Berberine is one of the main alkaloids of Rhizoma coptidis, proven to have anti-diabetic
potentials through activation of AMP activated protein kinase (AMPK) in liver and muscle …

Abstract Berberine from Rhizoma Coptidis is an oral hypoglycemic agent with anti-
dyslipidemia and anti-obesity activities. Its metabolic activity of regulating blood glucose and …

Berberine (BBR) is the main alkaloid of Coptis chinensis, which has been used as a folk
medicine to treat diabetes mellitus in Asian countries. We explored the possibility that 5 …

Glucose promotes insulin secretion primarily via its metabolism and the production of
metabolic coupling factors in beta-cells. The activation of AMP-activated protein kinase …