Prion-like mechanisms in Alzheimer's disease

RH Yin, L Tan, T Jiang, JT Yu - Current Alzheimer Research, 2014 - ingentaconnect.com
The misfolding and aggregation of specific proteins within nervous system occur in most age-
associated neurodegenerative diseases including Alzheimer's disease (AD). This kind of …

[HTML][HTML] Protein misfolding and spreading pathology in neurodegenerative diseases

DF Lázaro, A Bellucci, P Brundin… - Frontiers in Molecular …, 2020 - frontiersin.org
A common pathological hallmark among different neurodegenerative diseases is the
accumulation of aggregated proteins that might cause cellular dysfunction and, eventually …

Prions and neurodegenerative diseases: a focus on Alzheimer's disease

A Crestini, F Santilli, S Martellucci… - Journal of …, 2022 - content.iospress.com
Specific protein misfolding and aggregation are mechanisms underlying various
neurodegenerative diseases such as prion disease and Alzheimer's disease (AD). The …

Prion-like mechanisms in neurodegenerative diseases

B Frost, MI Diamond - Nature Reviews Neuroscience, 2010 - nature.com
Many non-infectious neurodegenerative diseases are associated with the accumulation of
fibrillar proteins. These diseases all exhibit features that are reminiscent of those of …

Invited Review: The role of prion‐like mechanisms in neurodegenerative diseases

Z Jaunmuktane, S Brandner - Neuropathology and Applied …, 2020 - Wiley Online Library
The prototype of transmissible neurodegenerative proteinopathies is prion diseases,
characterized by aggregation of abnormally folded conformers of the native prion protein. A …

Interaction between pathogenic proteins in neurodegenerative disorders

KA Jellinger - Journal of cellular and molecular medicine, 2012 - Wiley Online Library
Introduction The proteopathic basis of AD Protein interactions in PD Induction and spread of
protein aggregates in NDDs Conclusions The misfolding and progressive aggregation of …

Decoding the cellular trafficking of prion-like proteins in neurodegenerative diseases

C Hu, Y Yan, Y Jin, J Yang, Y Xi, Z Zhong - Neuroscience Bulletin, 2024 - Springer
The accumulation and spread of prion-like proteins is a key feature of neurodegenerative
diseases (NDs) such as Alzheimer's disease, Parkinson's disease, or Amyotrophic Lateral …

Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders

M Hasegawa, T Nonaka… - Pharmacology & …, 2017 - Elsevier
Prion-like propagation of abnormal intracytoplasmic proteins, which are the defining features
of major neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's …

The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration

M Costanzo, C Zurzolo - Biochemical Journal, 2013 - portlandpress.com
The misfolding and aggregation of specific proteins is a common hallmark of many
neurodegenerative disorders, including highly prevalent illnesses such as Alzheimer's and …

Attempt to untangle the prion-like misfolding mechanism for neurodegenerative diseases

D Sarnataro - International journal of molecular sciences, 2018 - mdpi.com
The misfolding and aggregation of proteins is the neuropathological hallmark for numerous
diseases including Alzheimer's disease, Parkinson's disease, and prion diseases. It is …