Rare and complex mutations of epidermal growth factor receptor, and efficacy of tyrosine kinase inhibitor in patients with non-small cell lung cancer

B Keam, DW Kim, JH Park, JO Lee, TM Kim… - International journal of …, 2014 - Springer
Background There are many complex and rare mutations in the epidermal growth factor
receptor (EGFR) gene in non-small cell lung cancer (NSCLC) other than the two classical …

Effectiveness of tyrosine kinase inhibitors on “uncommon” epidermal growth factor receptor mutations of unknown clinical significance in non–small cell lung cancer

JY Wu, CJ Yu, YC Chang, CH Yang, JY Shih… - Clinical cancer …, 2011 - AACR
Purpose: Clinical features of epidermal growth factor receptor (EGFR) mutations, L858R,
deletions in exon 19, T790M, and insertions in exon 20, in non–small cell lung cancer …

[HTML][HTML] Complex mutations in the epidermal growth factor receptor gene in non-small cell lung cancer

A Hata, H Yoshioka, S Fujita, K Kunimasa, R Kaji… - Journal of Thoracic …, 2010 - Elsevier
Introduction: Mutation of the epidermal growth factor receptor (EGFR) gene can predict the
efficacy of EGFR-tyrosine kinase inhibitors. Different mutations have been shown to co-occur …

[HTML][HTML] Activity of epidermal growth factor receptor-tyrosine kinase inhibitors in patients with non-small cell lung cancer harboring rare epidermal growth factor …

T De Pas, F Toffalorio, M Manzotti, C Fumagalli… - Journal of Thoracic …, 2011 - Elsevier
Introduction Mutations of the epidermal growth factor receptor (EGFR) have been proven to
predict activity of the EGFR-tyrosine kinase inhibitors (EGFR-TKI), gefitinib and erlotinib …

Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non–small cell lung cancer patients treated with gefitinib or …

DM Jackman, BY Yeap, LV Sequist, N Lindeman… - Clinical Cancer …, 2006 - AACR
Purpose: Somatic mutations in the epidermal growth factor receptor (EGFR) have been
detected in patients with non–small cell lung cancer (NSCLC) and are associated with …

[HTML][HTML] Clinical characteristics and response to tyrosine kinase inhibitors of patients with non-small cell lung cancer harboring uncommon epidermal growth factor …

Y Zhang, Z Wang, X Hao, X Hu, H Wang… - Chinese Journal of …, 2017 - ncbi.nlm.nih.gov
Objective To investigate the clinical features of patients with non-small cell lung cancer
(NSCLC) harboring uncommon epidermal growth factor receptor (EGFR) mutations, and the …

Double mutation and gene copy number of EGFR in gefitinib refractory non-small-cell lung cancer

M Tokumo, S Toyooka, S Ichihara, K Ohashi… - Lung cancer, 2006 - Elsevier
Mutations of the epidermal growth factor receptor (EGFR) gene have been reported in non-
small-cell lung cancer (NSCLC), especially in patients with adenocarcinoma and never …

Effectiveness of tyrosine kinase inhibitors in Japanese patients with non-small cell lung cancer harboring minor epidermal growth factor receptor mutations: results …

T Otsuka, M Mori, Y Yano, J Uchida… - Anticancer …, 2015 - ar.iiarjournals.org
Aim: Non-small cell lung cancer (NSCLC) with minor mutations in the epidermal growth
factor receptor (EGFR) gene, except for the common 15 base-pair deletions in exon 19 and …

Clinical course of patients with non–small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib

GJ Riely, W Pao, DK Pham, AR Li, N Rizvi… - Clinical cancer …, 2006 - AACR
Purpose: In patients with non–small cell lung cancer (NSCLC), mutations in the epidermal
growth factor receptor (EGFR) tyrosine kinase domain have been associated with sensitivity …

Good Response to Gefitinib in Lung Adenocarcinoma of Complex Epidermal Growth Factor Receptor (EGFR) Mutations with the Classical Mutation Pattern

SG Wu, YL Chang, YC Hsu, JY Wu, CH Yang… - The …, 2008 - academic.oup.com
Background. Epidermal growth factor receptor (EGFR) mutations are usually detected in
lung adenocarcinoma and are associated with a response to EGFR tyrosine kinase …