Indenoisoquinolinediones are a class of non-camptothecin topoisomerase I poisons that
display marked cytotoxic and potent antitumor properties. Currently three …

A number of novel dihydroindenoisoquinolines and indenoisoquinolinium salts were
synthesized and examined for cytotoxicity in cancer cell cultures and for inhibition of …

Carbohydrate moieties were strategically transported from the indolocarbazole
topoisomerase I (Top1) inhibitor class to the indenoisoquinoline system in search of …

Based on known heterocyclic topoisomerase II inhibitors and anticancer agents, various
indenoindolone derivatives were predicted as potential topoisomerase II–inhibiting …

ABSTRACT Topoisomerase I (TOP I) is a valuable molecular target for the development of
clinically used anticancer agents. Topoisomerase I is important for DNA replication andc ell …

A number of mono-or diaminoalkylated indeno [1, 2-c] isoquinolin-5, 11-diones analogs of 1
were synthesized and evaluated for their DNA binding affinities, topoisomerase inhibition …

Several indenoisoquinolines have shown promise as anticancer agents in clinical trials.
Incorporation of a nitrogen atom into the indenoisoquinoline scaffold offers the possibility of …

The discovery that certain indenoisoquinolines inhibit the religation reaction of DNA in the
topoisomerase I-DNA-indenoisoquinoline ternary complex led to a structure-based drug …

An intramolecular radical cyclization reaction of 4-bromo-3-arylisoquinolines 11a–c allowed
the efficient synthesis of 11-methylindenoisoquinolines 2a–c. 5-(2-Aminoethylamino) indeno …

11-Hydroxyindeno [1, 2-c] isoquinolines 12a–c were prepared as constrained forms of 3-
arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized …