The metabolic regulation of blood flow is central to guaranteeing an adequate supply of
blood to the tissues and microvascular network stability. It is assumed that vascular reactions …

Alterations in oxygen transport and use are integral to the development of multiple organ
failure; therefore, the ultimate goal of resuscitation is to restore effective tissue oxygenation …

After shock, persistent oxygen extraction deficit despite the apparent adequate recovery of
systemic hemodynamic and oxygen-derived variables has been a source of uncertainty and …

Shock, defined at a cellular level, is a condition in which oxygen delivery to the cells is not
sufficient to sustain cellular activity and support organ function. The central role of …

Maintenance of functional vascular networks requires structural adaptation of vessel
diameters in response to hemodynamic and metabolic conditions. The mechanisms by …

Microvascular alterations are a hallmark of sepsis and play a crucial role in its
pathophysiology. Such alterations are the result of overwhelming inflammation, which …

Organ function relies on microvascular networks to maintain homeostatic equilibrium, which
varies widely in different organs and during different physiological challenges. The …

Assessment of the adequacy of systemic O 2 delivery (DO 2) is central in the evaluation of
critically ill patients, but estimates of systemic DO 2 do not assess the effectiveness of …

PURPOSE: Recent studies reported that microcirculatory blood flow alterations occur in
patients with circulatory shock independent of arterial pressure but typically lack baseline …

This article presents a personal viewpoint of the shortcoming of conventional hemodynamic
resuscitation procedures in achieving organ perfusion and tissue oxygenation following …