Purpose The pharmacodynamics and therapeutic effects of extended-infusion (EI)
piperacillin–tazobactam therapy are reviewed, with an emphasis on growing evidence of its …

Introduction To enhance the probability of pharmacodynamic target attainment, piperacillin–
tazobactam can be administered as either a continuous or extended-infusion dosage …

Background. Piperacillin-tazobactam is frequently used to treat Pseudomonas aeruginosa
infections in critically ill patients. In an effort to improve clinical outcomes, an extended …

Study Objective. To compare the effectiveness of extended‐infusion piperacillin‐tazobactam
with that of similar‐spectrum, nonextended‐infusion β‐lactam antibiotics in the treatment of …

Background: Although intermittent bolus dosing is currently the standard of practice for many
antimicrobial agents, beta-lactams exhibit time-dependent bacterial killing. Maximizing the …

Purpose To summarize the current literature on the use and clinical efficacy of extended-
infusion (EI) beta-lactam antibiotics, including piperacillin–tazobactam, meropenem, and …

Studies evaluating the outcomes of an extended-infusion (EI) piperacillin-tazobactam dosing
strategy in specific cohorts of critically ill patients are lacking. A retrospective, pre …

β-Lactam antibiotics, such as piperacillin–tazobactam, are commonly administered
frequently throughout the day as intermittent infusions over a period of 30–60min. However …

Administration of β-lactam antibiotics by extended infusion optimizes the pharmacodynamic
properties and bactericidal activity of these agents resulting in a potential improvement in …

Study Objective. To compare continuous versus intermittent administration of piperacillin‐
tazobactam with regard to clinical, microbiologic, and economic outcomes. Design …