Meta-analysis: comparative efficacy of H2-receptor antagonists and proton pump inhibitors for reducing aspiration risk during anaesthesia depending on the …

I Puig, S Calzado, D Suarez, J Sanchez-Delgado… - Pharmacological …, 2012 - Elsevier
H2-receptor antagonists (H2RA) and proton pump inhibitors (PPI) are widely used for
aspiration prophylaxis in patients receiving general anaesthesia. Many randomized trials …

Acid suppression in the perioperative period

JR Pisegna, RG Martindale - Journal of clinical gastroenterology, 2005 - journals.lww.com
Aspiration of oropharyngeal and gastric contents during surgery, although infrequent, is a
recognized complication of general anesthesia that carries significant risk for serious …

Editorial II: Preanaesthetic H2 antagonists for acid aspiration pneumonia prophylaxis. Is there evidence of tolerance?

K Hirota, T Kushikata - British journal of anaesthesia, 2003 - academic.oup.com
Acid aspiration during induction of anaesthesia resulting in pneumonia is rare, with an
incidence of about three per 10 000 general anaesthetics. 1 2 However, this complication …

The effect of ranitidine versus proton pump inhibitors on gastric secretions: a meta‐analysis of randomised control trials

K Clark, LT Lam, S Gibson, D Currow - Anaesthesia, 2009 - Wiley Online Library
Aspiration of acid into the lungs is an infrequent but potentially devastating complication of
general anaesthesia. Routine practice often includes use of pharmacological agents to …

Acid aspiration prophylaxis in labour: a survey of UK obstetric units

N Calthorpe, M Lewis - International Journal of Obstetric Anesthesia, 2005 - Elsevier
BACKGROUND:: The risk of acid aspiration is still a major concern in pregnant patients. In
view of the increasing numbers of drugs available to decrease gastric acid production, it …

Think drink! Current fasting guidelines are outdated

M Thomas, T Engelhardt - BJA: British Journal of Anaesthesia, 2017 - academic.oup.com
Ever since the formative work of Curtis Mendelson1 in peripartum women, the need for
preoperative fasting has been propagated to help to minimize the risk of pulmonary …

Prophylaxis against acid aspiration syndrome: Single oral dose of H2‐antagonist on the evening before elective surgery

EG Gallagher, M White, S Ward, J Cottrell… - …, 1988 - Wiley Online Library
We have compared famotidine 40 mg, ranitidine 300 mg and placebo given in a single oral
dose at 2200 hours as the sole means of prophylaxis in 286 patients who underwent …

Comparison of omeprazole with cimetidine for prophylaxis of acid aspiration in elective surgery.

A Bouly, N Nathan, P Feiss - European journal of anaesthesiology, 1993 - europepmc.org
Gastric pH and volume were measured in four groups of 15 patients scheduled for elective
surgery. The patients were randomly allocated to receive either no antacid, oral omeprazole …

Interventions at caesarean section for reducing the risk of aspiration pneumonitis

S Paranjothy, JD Griffiths, HK Broughton… - International Journal of …, 2011 - Elsevier
BACKGROUND: Various interventions are used as prophylaxis for aspiration pneumonitis in
obstetric anaesthesia. This review, based on a Cochrane systematic review currently being …

The efficacy and optimum time of administration of ranitidine in the prevention of the acid aspiration syndrome

F Escolano, P Sierra, JC Ortiz, JC Cabrera… - …, 1996 - Wiley Online Library
In order to evaluate the efficacy of a single oral dose of ranitidine 150 mg and the optimum
time for its administration, we studied pH and volume measurements in 138 surgical …