• Regimens of once-a-day or twice-aday 0.25% timolol ophthalmic solution were compared
for efficacy and tolerability in a four-week study of 41 patients with chronic open-angle …

Timolol maleate is an effective agent of reducing intraocular pressure in patients with
chronic open-angle glaucoma. To date, there are no adverse side effects demonstrable with …

In a double-blind controlled study seven healthy subjects with normal eyes were given
alternatively a placebo or 80 or 160 mg of propranolol per day, with an interval of at least 1 …

The R‐enantiomer of timolol, L‐714,465, is considerably less potent as a beta 1‐and beta 2‐
adrenoceptor antagonist in animals than timolol, whilst only slightly less potent in reducing …

• A 34-year-old nursing woman with elevated intraocular pressure voluntarily and without
our knowledge applied 0.5% timolol maleate twice daily to her right eye. A milk sample 1.5 …

• The effect of topical timolol maleate on exercise performance was investigated in a
randomized double-blind study. Healthy young subjects underwent two graded maximal …

The hypotensive effect of Timolol eye drops (0.25 and 0.50%) in maintenance treatment of
64 patients with elevated intraocular pressure has been studied. The patients were treated …

To the Editor.—There is increasing evidence of systemic side effects secondary to topical
ocular administration of timolol maleate for the treatment of glaucoma. 1, 2 These systemic …

Plasma timolol levels were measured in our timolol-treated glaucoma patients employing
three protocols:(1) measurements in ten patients over age 60 on chronic timolol therapy …

The sympathetic system is composed of alpha and beta receptors. Beta blockers block the
beta effect competitively. They slow the heart and decrease its contractile strength. They …