[HTML][HTML] The study of primary and acquired resistance to first-line osimertinib to improve the outcome of EGFR-mutated advanced Non-small cell lung cancer patients …

A Ferro, GM Marinato, C Mulargiu, M Marino… - Critical Reviews in …, 2024 - Elsevier
The development of targeted therapy in epidermal growth factor receptor (EGFR)-mutated
non-small cell lung cancer (NSCLC) patients has radically changed their clinical …

[HTML][HTML] Acquired Resistance to Osimertinib in EGFR-Mutated Non-Small Cell Lung Cancer: How Do We Overcome It?

E Bertoli, E De Carlo, A Del Conte, B Stanzione… - International Journal of …, 2022 - mdpi.com
Osimertinib is currently the preferred first-line therapy in patients with non-small cell lung
cancer (NSCLC) with common epidermal growth factor receptor (EGFR) mutation and the …

[HTML][HTML] A review of research progress on mechanisms and overcoming strategies of acquired osimertinib resistance

F Qu, Y Zhou, W Yu - Anti-Cancer Drugs, 2022 - journals.lww.com
Targeted therapy with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-
TKIs) is the standard first-line treatment for advanced EGFR-mutated non-small cell lung …

[HTML][HTML] Toward the next generation EGFR inhibitors: an overview of osimertinib resistance mediated by EGFR mutations in non-small cell lung cancer

Y Li, T Mao, J Wang, H Zheng, Z Hu, P Cao… - Cell Communication and …, 2023 - Springer
Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is currently the
standard first-line therapy for EGFR-mutated advanced non-small cell lung cancer (NSCLC) …

[HTML][HTML] Mechanisms of resistance to osimertinib

C Lazzari, V Gregorc, N Karachaliou… - Journal of Thoracic …, 2020 - ncbi.nlm.nih.gov
The introduction of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)
has significantly improved the prognosis of advanced non-small cell lung cancer (NSCLC) …

[HTML][HTML] Osimertinib resistance: molecular mechanisms and emerging treatment options

G Gomatou, N Syrigos, E Kotteas - Cancers, 2023 - mdpi.com
Simple Summary Osimertinib, a third-generation epidermal growth factor receptor (EGFR)
tyrosine kinase inhibitor, is currently indicated as first-line therapy in patients with non-small …

Osimertinib in EGFR-mutated lung cancer: a review of the existing and emerging clinical data

CS Lee, M Milone, N Seetharamu - OncoTargets and therapy, 2021 - Taylor & Francis
The use of epidermal growth factor receptor (EGFR) inhibitors such as osimertinib has
improved outcomes and quality of life for patients with EGFR-mutated non-small cell lung …

[HTML][HTML] Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer

A Leonetti, S Sharma, R Minari, P Perego… - British journal of …, 2019 - nature.com
Osimertinib is an irreversible, third-generation epidermal growth factor receptor (EGFR)
tyrosine kinase inhibitor that is highly selective for EGFR-activating mutations as well as the …

Current treatment strategies for EGFR-mutated non-small cell lung cancer: from first line to beyond osimertinib resistance

T Araki, S Kanda, H Horinouchi… - Japanese Journal of …, 2023 - academic.oup.com
Osimertinib, a third-generation EGFR TKI, is the standard therapy for previously untreated
EGFR-mutated non-small cell lung cancer patients following the landmark FLAURA study …

Combatting acquired resistance to osimertinib in EGFR-mutant lung cancer

J Lee, Z Piotrowska, R Soo, BC Cho… - … Advances in Medical …, 2022 - journals.sagepub.com
The discovery of activating mutations in epidermal growth factor receptor (EGFR) in non-
small-cell lung cancer transformed the care and prognosis of patients and heralded the era …