Oligodendroglial injury is a pathological hallmark of many human white matter diseases,
including multiple sclerosis (MS) and periventricular leukomalacia (PVL). Critical regulatory …

Neurodegenerative disorders are marked by extensive neuronal apoptosis and gliosis.
Although several apoptosis-inducing agents have been described, understanding of the …

The sphingolipids galactosylceramide (GalCer), sulfatide (ST) and sphingomyelin (SM) are
essential for myelin stability and function. GalCer and ST are synthesized mostly from C22 …

Background Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's
disease dementia (PDD), and frontotemporal lobar dementia (FTLD) are characterized by …

In recent years, research on sphingolipids, particularly ceramides, has attracted increased
attention, revealing the important roles and many functions of these molecules in several …

Background Dopaminergic (DA) neurons in the ventral midbrain selectively degenerate in
Parkinson's disease (PD) in part because their oxidative environment in the substantia nigra …

Sphingolipids are a class of lipids highly enriched in the central nervous system (CNS),
which shows great diversity and complexity, and has been implicated in CNS development …

Multiple sclerosis (MS) is a demyelinating disorder characterized by massive
neurodegeneration and profound axonal loss. Since myelin is enriched with sphingolipids …

Ceramide, the precursor of all complex sphingolipids, is a potent signaling molecule that
mediates key events of cellular pathophysiology. In the nervous system, the sphingolipid …

For many decades, research on sphingolipids associated with neurodegenerative disease
focused on alterations in glycosphingolipids, particularly glycosylceramides (cerebrosides) …