Proteomics reveals novel oxidative and glycolytic mechanisms in type 1 diabetic patients' skin which are normalized by kidney-pancreas transplantation

F Folli, V Guzzi, L Perego, DK Coletta, G Finzi… - Plos one, 2010 - journals.plos.org
Background In type 1 diabetes (T1D) vascular complications such as accelerated
atherosclerosis and diffused macro-/microangiopathy are linked to chronic hyperglycemia …

Importance of identifying novel biomarkers of microvascular damage in type 1 diabetes

ML Marcovecchio - Molecular Diagnosis & Therapy, 2020 - Springer
Microvascular complications of type 1 diabetes, which primarily include diabetic kidney
disease, retinopathy, and neuropathy, are characterized by damage to the microvasculature …

High glucose causes distinct expression patterns of primary human skin cells by RNA sequencing

S Zhang, Z Ke, C Yang, P Zhou, H Jiang… - Frontiers in …, 2021 - frontiersin.org
Diabetes-related skin problems represent the most common long-term complications in
diabetes mellitus patients. These complications, which include diabetic dermopathy, diabetic …

Characterization of glycolytic enzymes and pyruvate kinase M2 in type 1 and 2 diabetic nephropathy

D Gordin, H Shah, T Shinjo, R St-Louis, W Qi… - Diabetes …, 2019 - Am Diabetes Assoc
OBJECTIVE Elevated glycolytic enzymes in renal glomeruli correlated with preservation of
renal function in the Medalist Study, individuals with≥ 50 years of type 1 diabetes …

Proteome profiling in the aorta and kidney of type 1 diabetic rats

M Al Hariri, M Elmedawar, R Zhu, MA Jaffa, J Zhao… - PLoS …, 2017 - journals.plos.org
Diabetes is associated with a number of metabolic and cardiovascular risk factors that
contribute to a high rate of microvascular and macrovascular complications. The risk factors …

Diabetes-induced proteome changes throughout development

D Johar, SM Ahmed, S El Hayek… - … Metabolic & Immune …, 2019 - ingentaconnect.com
Background: Diabetes Mellitus (DM) is a multisystemic disease involving the homeostasis of
insulin secretion by the pancreatic islet beta cells (β-cells). It is associated with hypertension …

[HTML][HTML] novel biomarkers for type 2 diabetes

TS Ahluwalia, TO Kilpeläinen, S Singh… - Frontiers in …, 2019 - frontiersin.org
Diabetes Mellitus, commonly known as diabetes, is a complex metabolic disorder
characterized by hyperglycemia over a prolonged period. The prevalence of diabetes is …

Proteomic discovery of diabetic nephropathy biomarkers

ML Merchant, JB Klein - Advances in chronic kidney disease, 2010 - Elsevier
Diabetes mellitus (DM) is a complex systemic disease with complications that result from
both genetic predisposition and dysregulated metabolic pathways. It is highly prevalent, with …

Multi-omics analysis of diabetic nephropathy reveals potential new mechanisms and drug targets

Q Sha, J Lyu, M Zhao, H Li, M Guo, Q Sun - Frontiers in genetics, 2020 - frontiersin.org
Diabetic nephropathy (DN) is one of the most common diabetic complications, which is the
major course of end-stage renal disease (ESRD). However, the systematical molecular …

Molecular mechanisms of diabetic nephropathy and its therapeutic intervention

S Yamagishi, K Fukami, S Ueda… - Current drug targets, 2007 - ingentaconnect.com
Diabetic nephropathy is a leading cause of end-stage renal failure, which could account for
disabilities and high mortality rates in patients with diabetes. Diabetic nephropathy seems to …