Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding
KN Iskander, MF Osuchowski… - Physiological …, 2013 - journals.physiology.org
Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …
substantial human morbidity resulting in hundreds of thousands of deaths each year …
Sepsis: The evolution in definition, pathophysiology, and management
B Gyawali, K Ramakrishna… - SAGE open …, 2019 - journals.sagepub.com
There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …
last three decades. This is driven in part due to the advances made in our understanding of …
[HTML][HTML] Recent advances in understanding and managing sepsis
D Berg, H Gerlach - F1000Research, 2018 - ncbi.nlm.nih.gov
The last two to three years provided several “big steps” regarding our understanding and
management of sepsis. The increasing insight into pathomechanisms of post-infectious …
management of sepsis. The increasing insight into pathomechanisms of post-infectious …
Pathophysiology of sepsis
Sepsis represents a dysregulated host response to infection leading to organ dysfunction.
Here, the pathogen triggers an initial exaggerated inflammatory-immune response that …
Here, the pathogen triggers an initial exaggerated inflammatory-immune response that …
[HTML][HTML] Focus: Death: Organ dysfunction in sepsis: An ominous trajectory from infection to death
C Caraballo, F Jaimes - The Yale journal of biology and medicine, 2019 - ncbi.nlm.nih.gov
Sepsis is a highly complex and lethal syndrome with highly heterogeneous clinical
manifestations that makes it difficult to detect and treat. It is also one of the major and most …
manifestations that makes it difficult to detect and treat. It is also one of the major and most …
Pathophysiology of sepsis
DG Remick - The American journal of pathology, 2007 - Elsevier
Sepsis remains a critical problem with significant morbidity and mortality even in the modern
era of critical care management. Multiple derangements exist in sepsis involving several …
era of critical care management. Multiple derangements exist in sepsis involving several …
Mechanisms of sepsis-induced organ dysfunction
Background: The past several years have seen remarkable advances in understanding the
basic cellular and physiologic mechanisms underlying organ dysfunction and recovery …
basic cellular and physiologic mechanisms underlying organ dysfunction and recovery …
Organ dysfunction as a new standard for defining sepsis
S Fujishima - Inflammation and Regeneration, 2016 - Springer
Despite advances in intensive care and the widespread use of standardized care included
in the Surviving Sepsis Campaign Guidelines, sepsis remains a leading cause of death, and …
in the Surviving Sepsis Campaign Guidelines, sepsis remains a leading cause of death, and …
Harmful molecular mechanisms in sepsis
D Rittirsch, MA Flierl, PA Ward - Nature Reviews Immunology, 2008 - nature.com
Sepsis and sepsis-associated multi-organ failure are major challenges for scientists and
clinicians and are a tremendous burden for health-care systems. Despite extensive basic …
clinicians and are a tremendous burden for health-care systems. Despite extensive basic …
Cellular mechanisms in sepsis
E Jean-Baptiste - Journal of intensive care medicine, 2007 - journals.sagepub.com
Mortality remains very high among septic patients despite the advanced treatments
rendered in intensive care units. The development of septic shock is multifactorial. Tissue …
rendered in intensive care units. The development of septic shock is multifactorial. Tissue …