Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …

The last two to three years provided several “big steps” regarding our understanding and
management of sepsis. The increasing insight into pathomechanisms of post-infectious …

Sepsis represents a dysregulated host response to infection leading to organ dysfunction.
Here, the pathogen triggers an initial exaggerated inflammatory-immune response that …

Sepsis is a highly complex and lethal syndrome with highly heterogeneous clinical
manifestations that makes it difficult to detect and treat. It is also one of the major and most …

Sepsis remains a critical problem with significant morbidity and mortality even in the modern
era of critical care management. Multiple derangements exist in sepsis involving several …

Background: The past several years have seen remarkable advances in understanding the
basic cellular and physiologic mechanisms underlying organ dysfunction and recovery …

Despite advances in intensive care and the widespread use of standardized care included
in the Surviving Sepsis Campaign Guidelines, sepsis remains a leading cause of death, and …

Sepsis and sepsis-associated multi-organ failure are major challenges for scientists and
clinicians and are a tremendous burden for health-care systems. Despite extensive basic …

Mortality remains very high among septic patients despite the advanced treatments
rendered in intensive care units. The development of septic shock is multifactorial. Tissue …