Background: In recent studies, the role of cytokines in traumatic brain injury (TBI) has been
identified and the intrathecal origin of cytokines demonstrated. The question, however …

Background: Despite the involvement of cytokine production in neurotrauma, there is still
controversy regarding cytokines levels and clinical outcome following severe traumatic brain …

Objective: Besides interleukin (IL)-10, accumulating evidence from in vitro studies has
indicated a strong antiinflammatory capacity for IL-13. A prospective clinical study was …

Background: Cytokines have been shown to be involved in traumatic brain injury (TBI). We
investigated the independent association between serum levels of IL-10 and TNF-α and …

Introduction The inflammatory response is an important part of the pathophysiology of
severe injury and, in particular, of severe traumatic brain injury (TBI). This study evaluates …

Abstract mdash;: Traumatic brain injury (TBI) is characterized by a high mortality which is
largely determined by the initial cerebral trauma, secondary brain injury or indirectly during a …

Background: Clinical outcome in patients with severe traumatic brain injury (TBI) depends
on both primary and secondary brain injuries. Neuroinflammation is an important secondary …

Patients with severe traumatic brain injury (TBI) show a profound acute-phase response.
Because interleukin-6 (IL-6) is an important mediator of these pathophysiological changes …

It has been reported that upwards of 50% of patients who survive an initial brain traumatic
insult subsequently die due to infection and multiple organ failure. A paralysis of cell …

Tohoku J. Exp. Med., 2007, 211 (4), 387-393── Because of complex pathophysiology and
severe consequences, traumatic brain injuries (TBI) are an important medical problem …