For vascular remodeling in hypertension, it is essential that vascular smooth muscle cells
(VSMCs) reshape in order to proliferate and migrate. The extracellular matrix (ECM) needs …

Vascular remodeling, defined as any enduring change in the size and/or composition of an
adult blood vessel, allows adaptation and repair. On the other hand, inappropriate …

The extracellular matrix (ECM) is a vital component of connective tissue, and collagen is a
major constituent. There is growing evidence that changes in the composition of the cardiac …

Geometric remodeling is an important component of vascular pathologies, including
restenosis and atherosclerosis. Although our understanding of the precise events involved …

The endothelium is one of the largest organ systems in the body, and data continue to
emerge regarding the importance of endothelial cell (EC) dysfunction in vascular aging and …

Matrix remodeling plays an important role in the physiological and pathological remodeling
of blood vessels. We specifically investigated the role of matrix metalloproteinase (MMP)-9 …

Arterial remodeling refers to the structural and functional changes of the vessel wall that
occur in response to disease, injury, or aging. Vascular smooth muscle cells (VSMC) play a …

Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a
major problem of public health. Over the years, life expectancy has considerably increased …

Intimal thickening occurs in blood vessels in response to injury or atherosclerosis. The
balance of migration and proliferation of vascular smooth muscle cells (VSMC) over death …

The extracellular matrix provides a structural framework essential for the functional
properties of vessel walls. The three dimensional organization of the extracellular matrix …