Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute to dopaminergic
dysfunction and symptom onset in psychosis, but it remains unclear whether this dysfunction …

Importance Despite the well-established role of striatal dopamine in psychosis, current views
generally agree that cortical dysfunction is likely necessary for the emergence of psychotic …

BackgroundGiven that only a subgroup of patients with schizophrenia responds to first-line
antipsychotic drugs, a key clinical question is what underlies treatment response …

Objective Striatal dopamine dysfunction caused by cortical abnormalities is a leading
hypothesis of schizophrenia. Although prefrontal cortical pathology is negatively correlated …

Background The striatum is abnormal in schizophrenia and possibly represents a common
neurobiological mechanism underlying psychotic disorders. Resting-state functional …

Aberrant dopamine function in the dorsal striatum and aberrant intrinsic functional
connectivity (iFC) between distinct cortical networks and thalamic nuclei are among the most …

BackgroundSchizophrenia (SZ) is a complex disorder characterized by a range of
behavioral and cognitive symptoms as well as structural and functional alterations in …

BACKGROUND: The theory that prefrontal cortex (PFC) dysfunction in schizophrenia leads
to excess subcortical dopamine has generated widespread interest because it provides a …

Background Anatomical connectivity between the thalamus and cortex, including the
prefrontal cortex (PFC), is abnormal in schizophrenia. Overlapping phenotypes, including …

Both psychotic illness and subclinical psychosis-like experiences (PLEs) have been
associated with cortico-striatal dysfunction. This work has largely relied on a discrete …