Secondary injury and inflammation after intracerebral haemorrhage: a systematic review and meta-analysis of molecular markers in patient brain tissue

JJM Loan, C Kirby, K Emelianova… - Journal of Neurology …, 2022 - jnnp.bmj.com
Background Inflammatory responses to intracerebral haemorrhage (ICH) are potential
therapeutic targets. We aimed to quantify molecular markers of inflammation in human brain …

An update on inflammation in the acute phase of intracerebral hemorrhage

S Chen, Q Yang, G Chen, JH Zhang - Translational stroke research, 2015 - Springer
Intracerebral hemorrhage (ICH) is a common and severe neurological disorder, which is
associated with high rates of mortality and morbidity. Despite extensive research into the …

[HTML][HTML] Comparison of humoral neuroinflammation and adhesion molecule expression in two models of experimental intracerebral hemorrhage

A Liesz, M Middelhoff, W Zhou, S Karcher… - … & Translational Stroke …, 2011 - Springer
Background Inflammatory cascades contribute to secondary injury after intracerebral
hemorrhage (ICH) via humoral factors and cell-mediated cytotoxicity. Several experimental …

Assessment of systemic cellular inflammatory response after spontaneous intracerebral hemorrhage

JH Tapia-Pérez, D Karagianis, R Zilke… - Clinical neurology and …, 2016 - Elsevier
Objective After spontaneous intracerebral hemorrhage (ICH) a local and systemic
inflammatory response is activated. Interleukin-6 (IL) is one of most relevant orchestrators of …

Inflammation after intracerebral hemorrhage

J Wang, S Doré - Journal of Cerebral Blood Flow & …, 2007 - journals.sagepub.com
Intracerebral hemorrhage (ICH) is a devastating clinical event without effective therapies.
Increasing evidence suggests that inflammatory mechanisms are involved in the …

Molecular biomarker of inflammatory response is associated with rebleeding in spontaneous intracerebral hemorrhage

KW Wang, CL Cho, HJ Chen, CL Liang… - European …, 2011 - karger.com
Background and Purpose: Rebleeding in spontaneous intracerebral hemorrhage (ICH) is a
major cause of morbidity and mortality among stroke survivors. Due to the links between …

Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

H Zhu, Z Wang, J Yu, X Yang, F He, Z Liu, F Che… - Progress in …, 2019 - Elsevier
Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has
high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic …

[HTML][HTML] Intracerebral proinflammatory cytokine increase in surgically evacuated intracerebral hemorrhage: a microdialysis study

L Tobieson, A Gard, K Ruscher, N Marklund - Neurocritical Care, 2022 - Springer
Background Treatment options for spontaneous intracerebral hemorrhage (ICH) are limited.
A possible inflammatory response in the brain tissue surrounding an ICH may exacerbate …

Anakinra in cerebral haemorrhage to target secondary injury resulting from neuroinflammation (ACTION): Study protocol of a phase II randomised clinical trial

MP Cliteur, AG van der Kolk, G Hannink… - European stroke …, 2024 - journals.sagepub.com
Background: Inflammation plays a vital role in the development of secondary brain injury
after spontaneous intracerebral haemorrhage (ICH). Interleukin-1 beta is an early pro …

Association of serum IL-6 (Interleukin 6) with functional outcome after intracerebral hemorrhage

AC Leasure, LR Kuohn, KN Vanent, MB Bevers… - Stroke, 2021 - Am Heart Assoc
Background and Objectives: IL-6 (interleukin 6) is a proinflammatory cytokine and an
established biomarker in acute brain injury. We sought to determine whether admission IL-6 …