Although chemotherapy is considered the mainstay of cancer therapy, unfortunate side
effects of chemotherapy create a continuous demand for developing other novel and specific …

Epigenetic modifications play a key role in the patho-physiology of many tumors and the
current use of agents targeting epigenetic changes has become a topic of intense interest in …

The DNA methyltransferase (DNMT) inhibitors azacytidine and decitabine are the most
successful epigenetic drugs to date and are still the most widely used as epigenetic …

This review presents the different human DNA methyltransferases (DNMTs), their biological
roles, their mechanisms of action and their role in cancer. The description of assays for …

DNA methylation is a major epigenetic mechanism that leads to inhibition of gene
transcription and is known to be involved in the pathogenesis of cancer. The effectors of …

DNA methylation is a mammalian epigenetic mark that participates to define where and
when genes are expressed, both in normal cells and in the context of diseases. Like other …

DNA methyltransferase inhibitors are widely used in preclinical and clinical studies, but poor
pharmacokinetics and low efficacy in solid tumors limit their therapeutic use. A new study …

Epimutations, such as the hypermethylation and epigenetic silencing of tumor suppressor
genes, play a role in the etiology of human cancers. In contrast to DNA mutations, which are …

DNA methylation, an epigenetic modification, regulates gene transcription and maintains
genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at …

DNA methylation is an epigenetic modification involved in gene expression regulation. In
cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …