Chronic treatment with simvastatin affects cannabinoid receptor type 1 and muscarinic receptors type 2/4 in different brain regions among sham and 6 …
N Mackovski - 2013 - ro.uow.edu.au
Background: Simvastatin is a hypolipidemic drug belonging to the family of statins. It has
been previously reported that simvastatin, among other statins, significantly prevented …
been previously reported that simvastatin, among other statins, significantly prevented …
Reversal effect of simvastatin on the decrease in cannabinoid receptor 1 density in 6-hydroxydopamine lesioned rat brains
N Mackovski, J Liao, R Weng, X Wei, R Wang, Z Chen… - Life sciences, 2016 - Elsevier
Abstract Aims Cannabinoid 1 (CB1) receptors are closely correlated to the dopaminergic
system and involved in cognitive function. Since statins have been used to regulate the …
system and involved in cognitive function. Since statins have been used to regulate the …
Simvastatin prevents dopaminergic neurodegeneration in experimental parkinsonian models: the association with anti-inflammatory responses
J Yan, Y Xu, C Zhu, L Zhang, A Wu, Y Yang, Z Xiong… - PLoS one, 2011 - journals.plos.org
Background In addition to their original applications to lowering cholesterol, statins display
multiple neuroprotective effects. N-methyl-D-aspartate (NMDA) receptors interact closely …
multiple neuroprotective effects. N-methyl-D-aspartate (NMDA) receptors interact closely …
Simvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats
Q Wang, PH Wang, C McLachlan, PTH Wong - Brain research, 2005 - Elsevier
Sprague–Dawley rats with unilateral lesion of the medial forebrain bundle by 6-
hydroxydopamine showed marked decrease in the expression of dopamine D1 and D2 …
hydroxydopamine showed marked decrease in the expression of dopamine D1 and D2 …
Chronic treatment with simvastatin upregulates muscarinic M1/4 receptor binding in the rat brain
Statins are increasingly being used for the treatment of a variety of conditions beyond their
original indication for cholesterol lowering. We previously reported that simvastatin affected …
original indication for cholesterol lowering. We previously reported that simvastatin affected …
Simvastatin reverses the downregulation of M1/4 receptor binding in 6-hydroxydopamine-induced parkinsonian rats: the association with improvements in long-term …
Q Wang, X Wei, H Gao, J Li, J Liao, X Liu, B Qin, Y Yu… - Neuroscience, 2014 - Elsevier
Background It is believed that muscarinic M1/4 receptors are closely correlated to the
dopaminergic system and are strongly involved in the pathogenesis of Parkinson's disease …
dopaminergic system and are strongly involved in the pathogenesis of Parkinson's disease …
Chronic treatment with simvastatin upregulates muscarinic M1/4 receptor binding in the rat brain
Statins are increasingly being used for the treatment of a variety of conditions beyond their
original indication for cholesterol lowering. We previously reported that simvastatin affected …
original indication for cholesterol lowering. We previously reported that simvastatin affected …
High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: the association with the up-regulation of NMDA receptor binding in the rat brain
Statins are widely being used for the treatment of a variety of conditions beyond their original
indication for lowering cholesterol. We have previously reported that simvastatin affected the …
indication for lowering cholesterol. We have previously reported that simvastatin affected the …
High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: The association with the up-regulation of NMDA receptor binding in the rat brain
Statins are widely being used for the treatment of a variety of conditions beyond their original
indication for lowering cholesterol. We have previously reported that simvastatin affected the …
indication for lowering cholesterol. We have previously reported that simvastatin affected the …
Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms
Neuro-inflammation and oxidative stress plays a key role in the pathophysiology of
Parkinson's disease (PD). Studies demonstrated that neuro-inflammation and associated …
Parkinson's disease (PD). Studies demonstrated that neuro-inflammation and associated …