The 6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (TIQ), salsolinol, is a substantial
constituent along with its mono-O-methylated metabolite (s) in urine obtained from alcoholic …

Brain concentrations of salsolinol (SAL), a simple tetrahydroisoquinoline (sTIQ)
condensation product of do‐pamine (DA) and acetaldehyde, are reported to increase in …

Carboxysalsolinol was found to be present in rat striatum, human urine and caudate nucleus
of post mortem human brain, according to capillary column gas chromatographic retention …

To explore the hypothesis that endogenous 1‐methyl‐6, 7‐dihydroxy‐1, 2, 3, 4‐
tetrahydroisoquinoline (salsolinol) might be involved in the etiology of alcoholism, its …

The tetrahydroisoquinoline (TIQ) salsolinol (SAL), a condensation product of dopamine and
pyruvate or acetaldehyde, is one of the neuropharmacologically active alkaloids in …

Salsolinol and salsoline were labelled with deuterium using an acidic exchange reaction in
2 HCl 2 H 2 O. Two deuterium atoms were incorporated in both compounds. The …

Using a microdialysis-HPLC technique in conscious rats, we examined the action of (R)-1-
methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline,(R)-salsolinol (R-Sal), a possible …

The analysis of the urine from 6 chronic alcoholics showed that (R)-and (S)-salsolinol were
detectable in 4 subjects, the R enantiomer was only found in one and that both enantiomers …

Background: Salsolinol, a neuropharmacologically active compound, is formed by the
condensation of acetaldehyde (AcH) with dopamine (DA) in the brain. The aim of our study …

Background: Dopamine (DA)‐derived tetrahydroisoquinolines (TIQs) are discussed as
neurochemical factors of addiction processes in alcoholism. In a prospective study, the …