Activation of hepatic stellate cells (HSC), a key event in liver fibrosis, is caused by
diminished adipogenic transcription. This study investigated whether Wnt signaling …

BACKGROUND/AIMS: Liver fibrosis is characterized by accumulation of extracellular matrix
proteins synthesized by activated hepatic stellate cells (HSCs). To understand molecular …

Activation of hepatic stellate cells (HSCs) is a pivotal cellular event in liver fibrosis.
Therefore, improving our understanding of the molecular pathways that are involved in these …

It is well known that hepatic stellate cells (HSC) develop into cells, which are thought to
contribute to liver fibrogenesis. Recent data suggest that HSC are progenitor cells with the …

Wnt signaling was implicated in pulmonary and renal fibrosis. Since Wnt activity is enhanced
in liver cirrhosis, Wnt signaling may also participate in hepatic fibrogenesis. Thus, we …

Quiescent hepatic stellate cells (HSCs), in response to liver injury, undergo characteristic
morphological transformation into proliferative, contractile and ECM-producing …

Liver fibrosis is a common wound-healing response to chronic liver injuries, including
alcoholic or drug toxicity, persistent viral infection, and genetic factors. Myofibroblastic …

Abstract β‑catenin, a core component of Wnt/β‑catenin signaling, has been shown to be an
important regulator of cellular proliferation and differentiation. Abnormal activation of Wnt/β …

Liver-specific β-catenin knockout (β-Catenin-LKO) mice have revealed an essential role of β-
catenin in metabolic zonation where it regulates pericentral gene expression and in initiating …

Postnatal liver development is characterized by hepatocyte growth, proliferation, and
functional maturation. Notably, canonical Wnt signaling in hepatocytes has been identified …