Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the
postsynaptic part of most excitatory synapses. Changes in the shape and size of dendritic …

Many actin cytoskeleton-regulating proteins control dendritic spine morphology and density,
which are cellular features often altered in autism spectrum disorder (ASD). Recent studies …

Highlights•Genetic and functional studies have provided important evidence pointing toward
a central role for dendritic spines on the pathogenesis of neuropsychiatric conditions.•Many …

Psychiatric and neurologic disorders ranging from mental retardation to addiction are
accompanied by structural and functional alterations of synaptic connections in the brain …

Dendritic spines are the sites of the majority of excitatory connections within the brain, and
form the post-synaptic compartment of synapses. These structures are rich in actin and have …

Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

Substantial progress has been made toward understanding the genetic architecture, cellular
substrates, brain circuits and endophenotypic profiles of neuropsychiatric disorders …

Dendrites and spines are the main neuronal structures receiving input from other neurons
and glial cells. Dendritic and spine number, size, and morphology are some of the crucial …

Dendritic spines are specialized structures on neuronal processes where the majority of
excitatory synapses are localized. Spines are highly dynamic, and their stabilization and …

The majority of excitatory synaptic input in the brain is received by small bulbous actin-rich
protrusions residing on the dendrites of glutamatergic neurons. These dendritic spines are …