Background Achieving weight loss is the cornerstone of the treatment of the metabolic
consequences of obesity, in particular of glucose intolerance. Objective To determine …

Longitudinal effects of a very low–carbohydrate (VLC) and a calorie‐matched high‐
carbohydrate (HC) weight reduction diet were compared in dietary obese Sprague–Dawley …

Objective It is controversial whether low‐carbohydrate diets are better suited for weight
control and metabolic health than high‐carbohydrate diets. This study examined whether …

Objectives Environmental factors such as a high-fat diet contribute to type 2 diabetes and
obesity. This study examined glycemia, insulin sensitivity, and β-cell function after switching …

Caloric restriction (CR) is of key importance in combating obesity and its associated
diseases. We aimed to examine effects of dietary macronutrient distribution on weight loss …

Methods: NZO mice were maintained on either standard rodent chow or an LCHFD from 6 to
15 weeks of age. Body weight, food intake and blood glucose were assessed weekly. Blood …

High fat feeding in rodents generally leads to obesity and insulin resistance whereas in
humans this is only seen if dietary carbohydrate is also high, the result of the anabolic effect …

A variety of inbred mouse strains have been used for research in metabolic disorders.
Despite being inbred, they display large inter-individual variability for many traits like food …

Pronounced weight loss was shown to improve adipocyte dysfunction and insulin sensitivity
in obese subjects. While bariatric surgery is frequently accompanied by adverse side effects …

High–fat (HF) diet-induced obesity and insulin insensitivity are associated with inflammation,
particularly in white adipose tissue (WAT). However, insulin insensitivity is apparent within …