Astrocytes play crucial roles in brain homeostasis and are regulatory elements of neuronal
and synaptic physiology. Astrocytic alterations have been found in Major Depressive …

Major depressive disorder (MDD) is a prevalent psychiatric disorder, and exposure to stress
is a robust risk factor for MDD. Clinical data and rodent models have indicated the negative …

Mood disorders have multiple phenotypes and complex underlying biological mechanisms
and, as such, there are no effective therapeutic strategies. A review of recent work on the …

Depression is a chronic, recurring, and serious mood disorder that afflicts up to 20% of the
global population. The monoamine hypothesis has dominated our understanding of the …

Recent studies have suggested that cortical astroglia play an important role in depressive-
like behaviors. Potential astroglial contributions have been proposed based on their known …

Background Major depressive disorder is a devastating psychiatric illness that affects
approximately 17% of the population worldwide. Astrocyte dysfunction has been implicated …

Astrocytes are an abundant subgroup of cells in the central nervous system (CNS) that play
a critical role in controlling neuronal circuits involved in emotion, learning, and memory. In …

Emotion-related neural networks are regulated in part by the activity of glial cells, and glial
dysfunction can be directly related to emotional diseases such as depression. Here, we …

Recent studies combining pharmacological, behavioral, electrophysiological and molecular
approaches indicate that depression results from maladaptive neuroplastic processes …

Cognitive dysfunctions, including impaired attention, learning, memory, planning and
problem solving, occur in depressive episodes, often persist during remission, predict …