Glucocorticoids are highly effective in the control of asthma and other chronic inflammatory
or immune diseases. The value of steroids in asthma became apparent soon after the …

Glucocorticoids are currently the most effective anti-inflammatory therapy for asthma.
However, a small subset of asthma sufferers do not respond to clinically relevant doses of …

Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic …

Although the majority of patients with asthma respond favorably to inhaled and systemic
glucocorticoids, up to 25% of patients with difficult-to-control asthma have poor clinical …

Although most patients with chronic asthma respond to corticosteroid therapy, a small subset
of asthmatics are unresponsive to corticosteroids and demonstrate persistent airway …

LEARNING OBJECTIVES: Reading this article will reinforce the reader's knowledge of the
definition, pathophysiology, differential diagnosis, and treatment of the steroid-resistant …

Glucocorticosteroids are the first-line therapy for controlling airway inflammation in asthma.
They bind intracellular glucocorticoid receptors to trigger increased expression of anti …

Background: Glucocorticoid-resistant bronchial asthma is characterized by failure of
corticosteroids to suppress key asthma-relevant, cell–mediated inflammatory responses in …

This paper is an overview of the diagnosis, differential diagnosis and cellular and molecular
mechanisms of glucocorticoid resistant asthma. It addresses the clinical definition and …

Inhaled glucocorticoids (GCs) are drugs widely used as treatment for asthma patients. They
prevent the recruitment and activation of lung immune and inflammatory cells and …