Asthma is a common medical condition affecting 300 million people worldwide. Airway
inflammation, smooth muscle bronchoconstriction leading to airflow obstruction, and mucous …

Asthma is now regarded as an inflammatory disease, and inhaled glucocorticoids (iGCs) are
recommended earlier in the course of treatment of patients with this disorder. Although iGCs …

Glucocorticoids are the mainstay for the treatment of chronic inflammatory diseases
including asthma and chronic obstructive pulmonary disease (COPD). However, it has been …

Allergen exposure can confound the management of asthma. To understand the potential
mechanisms by which allergens increase the steroid requirements in atopic asthmatics, we …

Although most patients with asthma symptoms are well controlled by inhaled glucocorticoids
(GCs), a subgroup of patients suffering from severe asthma respond poorly to GC therapy …

β2-Adrenergic receptor agonists and glucocorticoids are the two most effective treatments
for asthma, and used in combination they are more effective than either alone …

Glucocorticoid (GC)-insensitive asthma is a challenging clinical problem that can be
associated with life-threatening disease progression. The molecular basis of GC insensitivity …

BACKGROUND: Most chronic inflammatory diseases are well controlled by glucocorticoids.
However, a minority of patients fails to respond adequately to this treatment. OBJECTIVE …

A total of 37 chronic severe asthmatic patients with documented reversible airways
obstruction were classified as glucocorticoid sensitive or resistant according to changes in …

Corticosteroids are useful in the treatment of both allergic and idiosyncratic asthma.
Although the mechanisms of corticosteroid action in asthma are poorly understood, several …