Glucocorticoids are the mainstay of asthma therapy. They are primarily used to suppress
airway inflammation, which is the central pathological change in asthmatic patients' airways …

Complications observed in 51 patients receiving corticosteroids for greater than 1 year for
asthma and other chronic pulmonary diseases were compared retrospectively with 31 …

Airway epithelial damage and chronic inflammation are the main contributory factors in the
development of asthma. Until bronchoscopic techniques were developed, clear evidence of …

To improve understanding of the mechanisms of action of oral corticosteroids in asthma, we
have conducted a double-blind, placebo-controlled study with prednisolone (20 mg for 2 wk …

In many chronic inflammatory disorders, glucocorticoid (GC) insensitivity is a challenging
clinical problem associated with life-threatening disease progression. The molecular basis …

Background: Although widely used, little is known regarding the patterns of response that
subjects with severe asthma exhibit to oral glucocorticoid (GC) therapy. Methods: We …

Inhaled corticosteroids have been used successfully in the management of asthma for the
last 16 years,'ever since the discovery of agents with a favorable ratio of topical versus …

The role of inflammation in the pathogenesis of severe asthma chronically treated with high
doses of glucocorticoids is poorly understood. Despite this, treatment has been aimed at …

Lung function measures in patients with chronic obstructive pulmonary disease remain
insensitive to corticosteroid actions, in contrast to the clinical improvements observed in …

Asthma affects nearly 1 in 15 people in the United States and Europe. Although the cause or
causes of asthma remain unknown, its pathophysiology has been well enough …