Angiogenesis and lymphangiogenesis often occur in response to tissue injury or in the
presence of pathology (eg, cancer), and it is these types of environments in which …

Macrophages are supposed to play a key role in inflammatory and tumor angiogenesis.
Their importance derives from (1) their ubiquitous presence in normal and especially …

It is now well established that the functional domain of the macrophage M φ extends far
beyond its originally recognized role as a scavenger cell. The rich array of secretory …

Macrophages are primarily known as phagocytic innate immune cells, but are, in fact, highly
dynamic multi-taskers that interact with many different tissue types and have regulatory roles …

Cardiovascular disease (CVD) accounts for almost half of all deaths related to non-
communicable disease worldwide, making it the single largest global cause of mortality …

The ability of macrophages to promote vascular growth has been associated with the
secretion and local delivery of classic proangiogenic factors (eg, VEGF-A and proteases) …

The microcirculation is highly responsive to, and a vital participant in, the inflammatory
response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit …

Lymphangiogenesis is associated with pathological processes such as the metastatic
spread of carcinoma cells and organization of immunologically active lymphocytic infiltrates …

The lymphatic system provides important functions for tissue fluid homeostasis and immune
response. Lymphangiogenesis, the formation of new lymphatics, comprises a series of …

Chronic arterial occlusion leads to growth of collaterals-a process termed arteriogenesis, in
which macrophages play a prominent role in remodelling and growth. However, a detailed …