Molecular mechanisms of nitric oxide in cancer progression, signal transduction, and metabolism

V Somasundaram, D Basudhar… - Antioxidants & Redox …, 2019 - liebertpub.com
Significance: Cancer is a complex disease, which not only involves the tumor but its
microenvironment comprising different immune cells as well. Nitric oxide (NO) plays specific …

Immunomodulatory roles of nitric oxide in cancer: Tumor microenvironment says “NO” to antitumor immune response

J PeÑarando, E Aranda, A RodrÍguez-Ariza - Translational Research, 2019 - Elsevier
In recent years, an increasing number of studies have shown that there is an important
connection between nitric oxide (NO) and the pathology of malignant diseases, but we are …

Regulation of pleiotropic physiological roles of nitric oxide signaling

L Soundararajan, A Dharmarajan, P Samji - Cellular signalling, 2023 - Elsevier
Nitric Oxide (NO) is a highly diffusible, ubiquitous signaling molecule and a free radical that
is naturally synthesized by our body. The pleiotropic effects of NO in biological systems are …

The regulation of nitric oxide in tumor progression and therapy

Y Hu, J Xiang, L Su, X Tang - Journal of International …, 2020 - journals.sagepub.com
Nitric oxide (NO) is a ubiquitous gas with free radical groups that is soluble in water, and
which is involved in numerous physiological functions including inflammatory and immune …

Nitric oxide: the forgotten child of tumor metabolism

BS Rizi, A Achreja, D Nagrath - Trends in cancer, 2017 - cell.com
Nitric oxide (NO) is a signaling molecule with pleiotropic physiological roles in normal cells
and pathophysiological roles in cancer. NO synthetase expression and NO synthesis are …

Molecular mechanisms for discrete nitric oxide levels in cancer

LA Ridnour, DD Thomas, C Switzer, W Flores-Santana… - Nitric oxide, 2008 - Elsevier
Nitric oxide (NO) has been invoked in nearly every normal and pathological condition
associated with human physiology. In tumor biology, nitrogen oxides have both positive and …

The role of nitric oxide in cancer: master regulator or NOt?

FH Khan, E Dervan, DD Bhattacharyya… - International journal of …, 2020 - mdpi.com
Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis
depending on the source and concentration of NO. In this review, we discuss the …

NOS2 as an emergent player in progression of cancer

DD Thomas, DA Wink - Antioxidants & redox signaling, 2017 - liebertpub.com
Although the inducible form of nitric oxide synthase (NOS2) was initially shown to be a major
player as an antitumor component of the immune response, more recent data have shown …

[HTML][HTML] Inducible nitric oxide synthase-derived extracellular nitric oxide flux regulates proinflammatory responses at the single cell level

V Somasundaram, AC Gilmore, D Basudhar… - Redox Biology, 2020 - Elsevier
The role of nitric oxide (NO) in cancer progression has largely been studied in the context of
tumor NOS2 expression. However, pro-versus anti-tumor signaling is also affected by tumor …

The yin and yang of nitric oxide in cancer progression

AJ Burke, FJ Sullivan, FJ Giles, SA Glynn - Carcinogenesis, 2013 - academic.oup.com
Nitric oxide (NO) is a short-lived, pleiotropic molecule that affects numerous critical functions
in the body. Presently, there are markedly conflicting findings in the literature regarding NO …