A novel computational approach for drug repurposing using systems biology
Motivation Identification of novel therapeutic effects for existing US Food and Drug
Administration (FDA)-approved drugs, drug repurposing, is an approach aimed to …
Administration (FDA)-approved drugs, drug repurposing, is an approach aimed to …
Computational drug repurposing: current trends
Biomedical discovery has been reshaped upon the exploding digitization of data which can
be retrieved from a number of sources, ranging from clinical pharmacology to …
be retrieved from a number of sources, ranging from clinical pharmacology to …
A new computational drug repurposing method using established disease–drug pair knowledge
Motivation Drug repurposing is a potential alternative to the classical drug discovery
pipeline. Repurposing involves finding novel indications for already approved drugs. In this …
pipeline. Repurposing involves finding novel indications for already approved drugs. In this …
Network medicine for disease module identification and drug repurposing with the NeDRex platform
Traditional drug discovery faces a severe efficacy crisis. Repurposing of registered drugs
provides an alternative with lower costs and faster drug development timelines. However …
provides an alternative with lower costs and faster drug development timelines. However …
[HTML][HTML] A systematic review of computational approaches to understand cancer biology for informed drug repurposing
Cancer is the second leading cause of death globally, trailing only heart disease. In the
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …
[HTML][HTML] Computational approaches to drug repurposing and pharmacology
Data in the biological, chemical, and clinical domains are accumulating at ever-increasing
rates and have the potential to accelerate and inform drug development in new ways …
rates and have the potential to accelerate and inform drug development in new ways …
In silico methods for drug repurposing and pharmacology
Data in the biological, chemical, and clinical domains are accumulating at ever‐increasing
rates and have the potential to accelerate and inform drug development in new ways …
rates and have the potential to accelerate and inform drug development in new ways …
Pathway-based drug repositioning using causal inference
J Li, Z Lu - BMC bioinformatics, 2013 - Springer
Background Recent in vivo studies showed new hopes of drug repositioning through
causality inference from drugs to disease. Inspired by their success, here we present an in …
causality inference from drugs to disease. Inspired by their success, here we present an in …
Exploration of databases and methods supporting drug repurposing: a comprehensive survey
Drug development involves a deep understanding of the mechanisms of action and possible
side effects of each drug, and sometimes results in the identification of new and unexpected …
side effects of each drug, and sometimes results in the identification of new and unexpected …
Computational drug repurposing by exploiting large-scale gene expression data: Strategy, methods and applications
H He, H Duo, Y Hao, X Zhang, X Zhou, Y Zeng… - Computers in biology …, 2023 - Elsevier
De novo drug development is an extremely complex, time-consuming and costly task.
Urgent needs for therapies of various diseases have greatly accelerated searches for more …
Urgent needs for therapies of various diseases have greatly accelerated searches for more …