Melatonin is a neurohormone produced by the pineal gland that regulates sleep and
circadian functions. Melatonin also regulates inflammatory and immune processes acting as …

Melatonin is an immune modulator that displays both pro‐and anti‐inflammatory properties.
Proinflammatory actions, which are well documented by many studies in isolated cells or …

Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced
by the pineal gland, but also by other nonendocrine organs, of most mammals including …

Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity
occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including …

Melatonin modulates a wide range of physiological functions with pleiotropic effects on the
immune system. Despite the large number of reports implicating melatonin as an …

Melatonin is a small, highly conserved indole with numerous receptor-mediated and
receptor-independent actions. Receptor-dependent functions include circadian rhythm …

Melatonin is an indolamine synthesized and secreted by the pineal gland along with other
extrapineal sources including immune system cells, the brain, skin and the gastrointestinal …

Inflammation may be defined as the innate response to harmful stimuli such as pathogens,
injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic …

Melatonin (N‐acetyl‐5‐methoxytryptamine) was initially thought to be produced exclusively
in the pineal gland. Subsequently its synthesis was demonstrated in other organs, for …

Melatonin's pleiotropic actions begin from controlling day/night cycle and
hypothalamic/pituitary axes to, for example, vasomotor effects, immunomodulation, antilipid …