Expanded lung T-bet+ RORγT+ CD4+ T-cells in sarcoidosis patients with a favourable disease phenotype

Y Kaiser, R Lepzien, S Kullberg… - European …, 2016 - Eur Respiratory Soc
Disease phenotypes of pulmonary sarcoidosis are distinguished by clinical rather than
immunological criteria. We aimed to characterise patterns of CD4+ T-cell lineage plasticity …

Bronchoalveolar Lavage Fluid IFN‐γ+ Th17 Cells and Regulatory T Cells in Pulmonary Sarcoidosis

A Tøndell, T Moen, M Børset, Ø Salvesen… - Mediators of …, 2014 - Wiley Online Library
In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage
fluid, and elevated numbers of Th17 cells producing IFN‐γ have been observed in …

T‐cell phenotypes in bronchoalveolar lavage fluid, blood and lymph nodes in pulmonary sarcoidosis–indication for an airborne antigen as the triggering factor in …

P Darlington, H Haugom‐Olsen… - Journal of internal …, 2012 - Wiley Online Library
Darlington P, Haugom‐Olsen H, von Sivers K, Wahlström J, Runold M, Svjatoha V, Porwit A,
Eklund A, Grunewald J (Karolinska Institutet, Stockholm, Sweden). T‐cell phenotypes in …

Sarcoidosis is a Th1/Th17 multisystem disorder

M Facco, A Cabrelle, A Teramo, V Olivieri, M Gnoato… - Thorax, 2011 - thorax.bmj.com
Background and aims Sarcoidosis is characterised by a compartmentalisation of CD4+ T
helper 1 (Th1) lymphocytes and activated macrophages in involved organs, including the …

[HTML][HTML] Extensively disturbance of regulatory T cells-Th17 cells balance in stage II pulmonary sarcoidosis

J Ding, J Dai, H Cai, Q Gao, Y Wen - International Journal of …, 2017 - ncbi.nlm.nih.gov
Background: Sarcoidosis is a systemic inflammatory disorder characterized by granulomas.
Not enough evidences correlate the derangement of CD4+ T subsets, which have an impact …

[HTML][HTML] Imbalanced distribution of regulatory T cells and Th17. 1 cells in the peripheral blood and BALF of sarcoidosis patients: relationship to disease activity and the …

H Zhang, D Jiang, L Zhu, G Zhou, B Xie, Y Cui… - Frontiers in …, 2023 - frontiersin.org
Rationale Sarcoidosis is a granulomatous interstitial lung disease involving a complex
interplay among different cluster of differentiation 4 (CD4+) thymus cell (T-cell) subsets …

[HTML][HTML] T-Bet expression in peripheral Th17. 0 cells is associated with pulmonary function changes in sarcoidosis

NK Arger, S Machiraju, IE Allen, PG Woodruff… - Frontiers in …, 2020 - frontiersin.org
Background: Interferon-gamma (IFN-γ) is a key mediator of sarcoidosis-related
granulomatous inflammation. Previous findings of IFN-γ-producing Th17 cells in …

[HTML][HTML] Mass Cytometry Identifies Distinct Lung CD4+ T Cell Patterns in Löfgren's Syndrome and Non-Löfgren's Syndrome Sarcoidosis

Y Kaiser, T Lakshmikanth, Y Chen, J Mikes… - Frontiers in …, 2017 - frontiersin.org
Sarcoidosis is a granulomatous disorder of unknown etiology, characterized by
accumulation of activated CD4+ T cells in the lungs. Disease phenotypes Löfgren's …

Multiparameter phenotyping of T‐cell subsets in distinct subgroups of patients with pulmonary sarcoidosis

M Wikén, J Grunewald, A Eklund… - Journal of internal …, 2012 - Wiley Online Library
Wikén M, Grunewald J, Eklund A, Wahlström J (Respiratory Medicine Unit, Department of
Medicine Solna, Karolinska Institutet, Stockholm, Sweden). Multiparameter phenotyping of T …

Antigen-specific multifunctional T-cells in sarcoidosis patients with Löfgren's syndrome

M Wikén, M Ostadkarampour, A Eklund… - European …, 2012 - Eur Respiratory Soc
Sarcoidosis is a granulomatous disease of unknown aetiology, mainly affecting the lungs.
Recently, T-cell responses towards a specific mycobacterial protein, catalase–peroxidase …