Leukemia inhibitory factor inhibits the proliferation of gastric cancer by inducing G1‐phase arrest

G Xu, H Wang, W Li, Z Xue… - Journal of Cellular …, 2019 - Wiley Online Library
Leukemia inhibitory factor (LIF), a member of the interleukin‐6 cytokine family, plays a
complex role in cancer. LIF inhibits the proliferation and survival of several myeloid leukemia …

[HTML][HTML] Leukemia inhibitory factor: an important cytokine in pathologies and cancer

MM Jorgensen, P de la Puente - Biomolecules, 2022 - mdpi.com
Leukemia Inhibitory Factor (LIF) is a member of the IL-6 cytokine family and is expressed in
almost every tissue type within the body. Although LIF was named for its ability to induce …

The emerging role of leukemia inhibitory factor in cancer and therapy

C Zhang, J Liu, J Wang, W Hu, Z Feng - Pharmacology & therapeutics, 2021 - Elsevier
Leukemia inhibitory factor (LIF) is a multi-functional cytokine of the interleukin-6 (IL-6)
superfamily. Initially identified as a factor that inhibits the proliferation of murine myeloid …

Leukemia inhibitory factor induces apoptosis and proliferation of human carcinoma cells through different oncogene pathways

H Kamohara, K Sakamoto, T Ishiko… - … journal of cancer, 1997 - Wiley Online Library
Leukemia inhibitory factor (LIF) affects the growth of carcinoma cells, and we thus analyzed
its underlying mechanisms. Carcinoma cells constitutively express LIF mRNA, and 23 lines …

[HTML][HTML] LIF is a new p53 negative regulator

J Liu, H Yu, W Hu - Journal of nature and science, 2015 - ncbi.nlm.nih.gov
Leukemia inhibitory factor (LIF), a cytokine that belongs to the interleukin-6 family, regulates
multiple important biological functions. Recently, we found that LIF is an important negative …

Leukemia inhibitory factor, a double-edged sword with therapeutic implications in human diseases

J Wang, CY Chang, X Yang, F Zhou, J Liu, Z Feng… - Molecular Therapy, 2023 - cell.com
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine of the interleukin-6 (IL-6)
superfamily. LIF was initially discovered as a factor to induce the differentiation of myeloid …

Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expression

H Kamohara, M Ogawa, T Ishiko… - International …, 2007 - spandidos-publications.com
Leukemia inhibitory factor (LIF) is a pleiotrophic cytokine, which plays an important role in
inducing cancer cachexia. We have previously reported that LIF promotes cell proliferation …

Leukemia‐inhibitory factor stimulates breast, kidney and prostate cancer cell proliferation by paracrine and autocrine pathways

P Kellokumpu‐Lehtinen, M Talpaz… - … journal of cancer, 1996 - Wiley Online Library
Leukemia‐inhibitory factor (LIF) is an inflammatory cytokine with pleiotropic activities. LIF
was originally described as a differentiation factor of a murine leukemia cell line and was …

Leukemia inhibitory factor promotes gastric cancer cell proliferation, migration, and invasion via the LIFR–Hippo–YAP pathway

SB Bian, Y Yang, WQ Liang, KC Zhang… - Annals of the New …, 2021 - Wiley Online Library
The long‐term outcome of gastric cancer (GC) patients remains unsatisfactory despite some
recent improvements. Leukemia inhibitory factor (LIF) is a prognostic biomarker for some …

[HTML][HTML] The regulation of leukemia inhibitory factor

X Yue, L Wu, W Hu - Cancer cell & microenvironment, 2015 - ncbi.nlm.nih.gov
Leukemia inhibitory factor (LIF), a secreted cytokine, plays an important role in a wide array
of biological processes including inducing differentiation of leukemia cell, inflammatory …