A comprehensive, biophysically accurate, computational model of vascular endothelial
growth factor (VEGF) family member interactions with endothelial cell surface receptors was …

The vascular endothelial growth factor (VEGF) family of cytokines is involved in the
maintenance of existing adult blood vessels as well as in angiogenesis, the sprouting of new …

Angiogenesis (neovascularization) plays a crucial role in a variety of physiological and
pathological conditions including cancer, cardiovascular disease, and wound healing …

The vascular endothelial growth factor receptors (VEGFR) play a significant role in
angiogenesis, the formation of new blood vessels from existing vasculature. Systems …

The two most abundant secreted isoforms of vascular endothelial growth factor A (VEGF 165
and VEGF 121) are formed as a result of differential splicing of the VEGF-A gene. VEGF 165 …

Placental growth factor (PlGF) competes with vascular endothelial growth factor (VEGF) for
binding to VEGF receptor (VEGFR)-1 but does not bind VEGFR2. Experiments show that …

Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis–the growth of
new microvessels from existing microvasculature. Angiogenesis is a complex process …

Neuropilin-1 (Nrp1) is an essential receptor for angiogenesis that binds to VEGF-A. Nrp1
binds directly to VEGF-A with high affinity, but the nature of their selective binding has …

Vascular endothelial growth factor (VEGF) acts as a hierarchically high switch of the
angiogenic cascade by interacting with its high affinity VEGF receptors and with neuropilin …

The central role of vascular endothelial growth factor (VEGF) in angiogenesis in health and
disease makes it attractive both as a therapeutic target for anti-angiogenic drugs and as a …