Molecular targets and cancer therapeutics: discovery, development and clinical validation

BA Teicher - Drug Resistance Updates, 2000 - Elsevier
The AACR-NCI-EORTC International Conference on Molecular Targets and Cancer
Therapeutics held in Washington, DC on 16–19 November 1999 provided a forum for …

Targeted cancer therapeutics

WN Hait - Cancer research, 2009 - AACR
Targeted therapies can be defined as drugs developed against a specific target based on its
important biological function in cancer. In contrast, nontargeted therapies are drugs …

New cancer therapeutics: target-specific in, cytotoxics out?

HJ Broxterman, NH Georgopapadakou - Drug resistance updates, 2004 - Elsevier
The International Conference on Molecular Targets and Therapeutics, jointly sponsored by
the American Association for Cancer Research (AACR), National Cancer Institute (NCI) and …

Antitumor drugs and their targets

Z Dembic - Molecules, 2020 - mdpi.com
Through novel methodologies, including both basic and clinical research, progress has
been made in the therapy of solid cancer. Recent innovations in anticancer therapies …

Innovation in oncology drug development

M Huber, B Huber - Journal of Oncology, 2019 - Wiley Online Library
Significant progress has been made in our understanding of the molecular lesions
responsible for tumor cells to exhibit uncontrolled growth while circumventing normal …

The impact of molecular targets in cancer drug development: major hurdles and future strategies

A Hebar, P Valent, E Selzer - Expert review of clinical …, 2013 - Taylor & Francis
The last decades were characterized by enormous technological advances resulting in a
better understanding of disease pathologies and improvement of treatment strategies. The …

Screening and identification of molecular targets for cancer therapy

A Abdelmoez, DC Coraça-Huber, GC Thurner… - Cancer letters, 2017 - Elsevier
In recent decades, targeted therapeutics have significantly improved therapy results in
patients with malignant tumors of different origins. However, malignant diseases …

Evolution of targeted therapies in cancer: opportunities and challenges in the clinic

S Santhosh, P Kumar, V Ramprasad… - Future Oncology, 2015 - Future Medicine
Targeted therapies have changed the course of cancer treatment in recent years. By
reducing toxicity and improving outcome, these new generations of precision medicines …

[HTML][HTML] Molecular targeted therapy of cancer: The progress and future prospect

X Ke, L Shen - Frontiers in Laboratory Medicine, 2017 - Elsevier
Cancer has become a major public health problem worldwide. Researches focus on the
new approaches for cancer treatments that involve the specific targets of the cancer disease …

[HTML][HTML] Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

U Anand, A Dey, AKS Chandel, R Sanyal, A Mishra… - Genes & …, 2023 - Elsevier
Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …