The Division of Cancer Treatment, Diagnosis and Centers of the National Cancer Institute
(NCI) has a large program in clinical cancer therapeutics development. It currently holds …

Translating existing and emerging knowledge of cancer biology into effective novel
therapies remains a great challenge in drug discovery. A firm understanding of the target …

Following two decades of research on the biology of cancer and in particular of lung cancer,
we have now a large number of molecular targets that can be utilized to create specific …

New molecular insight reveals novel points of attack for targeted cancer therapy. The recent
advances in cancer genomics and novel insight into the complex biology of cancer make the …

Molecular targeted therapies are revolutionized therapeutics which interfere with specific
molecules to block cancer growth, progression, and metastasis. Many molecular targeted …

Chemotherapeutic interventions in cancer patients are limited by the appearance of
chemoresistance. For instance, advanced lung and ovarian cancer patients relapse …

The medical history of cancer began millennia ago. Historical findings of patients with
cancer date back to ancient Egyptian and Greek civilizations, where this disease was …

Therapeutic management of cancer has undergone tremendous conceptual advance over
the last couple of decades. Not only are we better acquainted with the intricate mechanisms …

Since the last edition of this book, major advances have been made in our understanding of
key pathways that control tumor progression. This has led to the development of new …

Rapid and affordable tumor profiling has led to an explosion of genomic data that is
facilitating the development of new cancer therapies. The potential of therapeutic strategies …