Importance of the field: The development of targeted anticancer therapies stems from
advances in molecular biology. New agents range from antibodies that form complexes with …

Chemotherapeutic drugs kill cancer cells or control their progression all over the patient's
body, while radiation-and surgery-based treatments perform in a particular site. Based on …

Cancer is one of the leading causes of death in the United States along with heart disease.
The hallmark of cancer treatment has been conventional chemotherapy. Chemotherapeutic …

There is an apparent need to improve the speed and efficiency of oncological drug
development. Furthermore, strategies traditionally applied to the development of standard …

We have made remarkable progress in our understanding of the pathophysiology of cancer.
This improved understanding has resulted in increasingly effective targeted therapies that …

A new approach to cancer drug discovery targets molecules important in cancer
pathogenesis. This approach is thought to be of greater promise than the antiproliferative …

Drug resistance remains the thorniest obstacle in developing improved systemic therapies
for disseminated cancer. The combination of genetic instability together with the great …

The hope that anti-angiogenic therapy might be the panacea for cancer has not yet been
realized. There are many possible reasons for this, including endothelial and tumor cell …

With unprecedented understanding of molecular events underlying human cancer in this
genomic era, a large number of drugs specifically targeting hypothesized oncogenic drivers …

The upcoming decade of precision medicine for cancer is moving from the translation of
specific genetic findings into clinically relevant improvement to the qualitative analyses of …