Cell-subtype specific effects of genetic variation in the aging and Alzheimer cortex
The relationship between genetic variation and gene expression in individual brain cell
types and subtypes has remained elusive. Here, we generated single-nucleus RNA …
types and subtypes has remained elusive. Here, we generated single-nucleus RNA …
Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain
The relationship between genetic variation and gene expression in brain cell types and
subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data …
subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data …
Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease
Background Identifying and understanding the functional role of genetic risk factors for
Alzheimer disease (AD) has been complicated by the variability of genetic influences across …
Alzheimer disease (AD) has been complicated by the variability of genetic influences across …
The complex genetic architecture of Alzheimer's disease: novel insights and future directions
SJ Andrews, AE Renton, B Fulton-Howard… - …, 2023 - thelancet.com
Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …
disorder and the most common form of dementia. AD is highly heritable, with heritability …
Single-cell epigenomic identification of inherited risk loci in Alzheimer's and Parkinson's disease
Genome-wide association studies (GWAS) have identified thousands of variants associated
with disease phenotypes. However, the majority of these variants do not alter coding …
with disease phenotypes. However, the majority of these variants do not alter coding …
Pathway-specific genetic risk for Alzheimer's disease differentiates regional patterns of cortical atrophy in older adults
S Caspers, ME Röckner, C Jockwitz, N Bittner… - Cerebral …, 2020 - academic.oup.com
Brain aging is highly variable and represents a challenge to delimit aging from disease
processes. Moreover, genetic factors may influence both aging and disease. Here we …
processes. Moreover, genetic factors may influence both aging and disease. Here we …
Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease
Many of the Alzheimer's disease (AD) risk genes are specifically expressed in microglia and
astrocytes, but how and when the genetic risk localizing to these cell types contributes to AD …
astrocytes, but how and when the genetic risk localizing to these cell types contributes to AD …
A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores
Background More than 75 common variant loci account for only a portion of the heritability
for Alzheimer's disease (AD). A more complete understanding of the genetic basis of AD can …
for Alzheimer's disease (AD). A more complete understanding of the genetic basis of AD can …
Multi-region brain transcriptomes uncover two subtypes of aging individuals with differences in Alzheimer risk and the impact of APOEε4
The heterogeneity of the older population suggests the existence of subsets of individuals
which share certain brain molecular features and respond differently to risk factors for …
which share certain brain molecular features and respond differently to risk factors for …
A landscape of the genetic and cellular heterogeneity in Alzheimer disease
Background Alzheimer disease (AD) has substantial genetic, molecular, and cellular
heterogeneity associated with its etiology. Much of our current understanding of the main AD …
heterogeneity associated with its etiology. Much of our current understanding of the main AD …