It is well known that iron (Fe) is transported to the mitochondrion for heme synthesis.
However, only recently has the importance of this organelle for many other facets of Fe …

Iron is essential for life. Its coordinated distribution between intracellular compartments and
the adaptation of iron uptake to intracellular demands are central for a balanced iron …

In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

Biogenesis of iron-sulfur (Fe/S) proteins in eukaryotes is an essential process involving the
mitochondrial iron-sulfur cluster (ISC) assembly and export machineries and the cytosolic …

Iron–sulfur (Fe/S) clusters belong to the most ancient protein cofactors in life, and fulfill
functions in electron transport, enzyme catalysis, homeostatic regulation, and sulfur …

Iron is essential for many cellular processes, but cellular iron homeostasis must be
maintained to ensure the balance of cellular signaling processes and prevent disease. Iron …

In addition to their well-established role in providing the cell with ATP, mitochondria are the
source of iron-sulfur clusters (ISCs) and heme–prosthetic groups that are utilized by proteins …

Highlights•Mitochondria contain the conserved ABC transporter Atm1 in the inner
membrane.•Atm1 is crucial for cytosolic-nuclear iron–sulfur protein biogenesis.•Atm1 is …

Iron plays an essential role in cellular metabolism and biological processes. However, due
to its intrinsic redox activity, free iron is a potentially toxic molecule in cellular biochemistry …

Protein controlled iron homeostasis is essential for maintaining appropriate levels and
availability of metal within cells. Recently, two iron chaperones have been discovered that …