Mitochondria supply cells with ATP, heme, and iron sulfur clusters (ISC), and mitochondrial
energy metabolism involves both heme-and ISC-dependent enzymes. Here, we show that …

Mitochondria play a key role in iron metabolism in that they synthesize heme, assemble iron–
sulfur (Fe/S) proteins, and participate in cellular iron regulation. Here, we review the latter …

Iron is required for a barrage of essential biochemical functions in virtually every species of
life. Perturbation of the availability or utilization of iron in these functions or disruption of …

Mitochondrial iron is indispensable for heme biosynthesis and iron–sulfur cluster assembly.
Several mitochondrial transmembrane proteins have been implicated to function in the …

Work during the past 14 years has shown that mitochondria are the primary site for the
biosynthesis of iron–sulfur (Fe/S) clusters. In fact, it is this process that renders mitochondria …

Handling a life‐supporting yet redox‐active metal like iron represents a significant challenge
to cells and organisms that must not only tightly balance intra‐and extracellular iron …

Mitochondria decay with age from oxidative damage and loss of protective mechanisms.
Resistance, repair, and replacement mechanisms are essential for mitochondrial …

An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

Iron–sulfur clusters (Fe–S) are one of the most ancient, ubiquitous and versatile classes of
metal cofactors found in nature. Proteins that contain Fe–S clusters constitute one of the …

In humans, the bulk of iron in the body (over 75%) is directed towards heme-or Fe–S cluster
cofactor synthesis, and the complex, highly regulated pathways in place to accomplish …