The endoplasmic reticulum (ER)–mitochondria encounter structure (ERMES) is a protein
complex that physically tethers the two organelles to each other and creates the physical …

Growing evidence supports a role for mitochondrial iron metabolism in the pathophysiology
of neurodegenerative disorders such as Friedreich ataxia (FRDA) and Parkinson disease …

In eukaryotes, mitochondrial iron-sulfur cluster (ISC), export and cytosolic iron-sulfur cluster
assembly (CIA) machineries carry out biogenesis of iron-sulfur (Fe-S) clusters, which are …

Systemic iron homeostasis needs to be tightly controlled, as both deficiency and excess iron
cause major global health concerns, such as iron deficiency anemia, hemochromatosis, etc …

Iron–sulfur cluster proteins play key roles in a multitude of physiological processes;
including gene expression, nitrogen and oxygen sensing, electron transfer, and DNA repair …

Iron− sulfur (Fe− S) proteins contain prosthetic groups consisting of two or more iron atoms
bridged by sulfur ligands, which facilitate multiple functions, including redox activity …

Fe-S cluster biogenesis is a multistep process that involves a complex sequence of
catalyzed protein–protein interactions and coupled conformational changes between the …

Iron is an essential nutrient for mitochondrial metabolic processes, including mitochondrial
respiration. Ferritin complexes store excess iron and protect cells from iron toxicity …

Iron is a mineral essential for blood production and a variety of critical cellular functions.
Altered iron metabolism has been increasingly observed in many diseases and disorders …

Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient
amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is …