Available literature on the use of pharmacologic agents for the treatment of sleep-disordered
breathing was reviewed by evidenced-based methodology. Evidence tables were created …

The extensive investigation into complex interactions of breathing and sleep have produced
answers to numerous important questions, but it is clear that many of the most important …

We hope that the reader is impressed with the relatively limited amount of information
available about the effects of drugs on breathing during sleep in both normal subjects and …

William C. Orr, Ph. D. since the late 1960s a voluminous literature has accumulated
testifYing to the ubiquity of sleeprelated breathing disorders. The realization that such …

Complaints of poor sleep are very common in people with chronic respiratory disorders. In
patients with chronic obstructive pulmonary disease (COPD), poor sleep may be due to …

Central sleep apnea is a disorder characterized by apneic episodes during sleep with no
associated ventilatory effort. More commonly than not these apneas are seen in patients …

Introduction: Obstructive sleep apnea syndrome is a common public health problem in the
general population. The important health-related consequences of obstructive sleep apnea …

Approximately half of patients with sleep-disordered breathing (SDB) also experience
insomnia. The relationship between these two common sleep disorders is complex and …

Treatment of obstructive sleep apnea (OSA) has developed over the last 25 years from
tracheostomy to a variety of options, including weight loss, nasal continuous positive airway …

Sleep entails a profound alteration in the function of the central nervous system. Sensory
avenues may be blocked and many motor systems inactivated. The giant neuronal galaxy …